TY - JOUR
T1 - The influence of aloe vera with mesenchymal stem cells from dental pulp on bone regeneration
T2 - characterization and treatment of non-critical defects of the tibia in rats
AU - Soares, Isadora Mello Vilarinho
AU - Fernandes, Gustavo Vicentis de Oliveira
AU - Cavalcante, Larissa Cordeiro
AU - Leite, Yulla Klinger Pereira de Carvalho
AU - Bezerra, Dayseanny de Oliveira
AU - Carvalho, Maria Acelina Martins de
AU - Carvalho, Carmen Milena Rodrigues Siqueira
PY - 2019
Y1 - 2019
N2 - Objective: This study aimed to evaluate the inflammatory effect and bone formation in sterile surgical failures after implantation of a collagen sponge with mesenchymal stem cells from human dental pulp (hDPSCs) and Aloe vera. Material and Methods: Rattus norvegicus (n=75) were divided into five experimental groups according to treatment: G1) control (blood clot); G2) Hemospon®; G3) Hemospon® in a culture medium enriched with 8% Aloe vera; G4) Hemospon® in a culture medium containing hDPSCs and G5) Hemospon® in a culture medium enriched with 8% Aloe vera and hDPSCs. On days 7, 15 and 30, the animals were euthanized, and the tibia was dissected for histological, immunohistochemistry and immunofluorescence analyses. The results were analyzed using nonparametric Kruskal-Wallis test and Dunn’s post-test. Results: On days 7 and 15, the groups with Aloe vera had less average acute inflammatory infiltrate compared to the control group and the group with Hemospon® (p
AB - Objective: This study aimed to evaluate the inflammatory effect and bone formation in sterile surgical failures after implantation of a collagen sponge with mesenchymal stem cells from human dental pulp (hDPSCs) and Aloe vera. Material and Methods: Rattus norvegicus (n=75) were divided into five experimental groups according to treatment: G1) control (blood clot); G2) Hemospon®; G3) Hemospon® in a culture medium enriched with 8% Aloe vera; G4) Hemospon® in a culture medium containing hDPSCs and G5) Hemospon® in a culture medium enriched with 8% Aloe vera and hDPSCs. On days 7, 15 and 30, the animals were euthanized, and the tibia was dissected for histological, immunohistochemistry and immunofluorescence analyses. The results were analyzed using nonparametric Kruskal-Wallis test and Dunn’s post-test. Results: On days 7 and 15, the groups with Aloe vera had less average acute inflammatory infiltrate compared to the control group and the group with Hemospon® (p
KW - Bone regeneration
KW - Herbal medicines
KW - Osteopontin
KW - Stem cell transplantation
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85064965726&partnerID=8YFLogxK
U2 - 10.1590/1678-7757-2018-0103
DO - 10.1590/1678-7757-2018-0103
M3 - Article
C2 - 30994771
AN - SCOPUS:85064965726
SN - 1678-7757
VL - 27
JO - Journal of Applied Oral Science
JF - Journal of Applied Oral Science
M1 - e20180103
ER -