The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis

Simone Beccari, Luı́s Teixeira, Pernille Rørth

Research output: Contribution to journalArticlepeer-review

123 Citations (Scopus)

Abstract

During Drosophila oogenesis, border cells perform a stereotypic migration. Slbo, a C/EBP transcription factor, is required for this migration. Here we identify Drosophila Stat92E (signal transducer and activator of transcription) in a screen for gain-of-function suppressors of the slbo mutant phenotype. By clonal analysis for Stat92E and hop (Drosophila JAK) mutants we find that the JAK/STAT pathway is required in border cells for their migration. The activating ligand for the pathway, Unpaired, is expressed in polar cells. Polar cells are specialized cells which can induce border cell fate in anterior follicle cells. On its own, ectopic expression of Unpaired can induce ectopic expression of border cell markers including Slbo. However, Stat92E mutant cells still express normal levels of Slbo protein, thus Stat92E must regulate other targets critical for border cell migration.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalMechanisms of Development
Volume111
Issue number1-2
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Border cell
  • Cell migration
  • Ectopic expression
  • JAK/STAT pathway
  • Oogenesis

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