Abstract
The application of omics ranges from drug discovery and development to diagnosis of diseases, by following their progression, improving efficacy and safety of treatments, optimizing patient selection and identification of responders/nonresponders, adapting dose regimens of drugs, and helping to decide which therapy is most appropriate. For obvious reasons an integrated approach should be followed as a strategy to avoid misinterpretations of data. For example, changes found at the gene level may not necessarily translate into altered levels of proteins. Here, we address the basis of genomics and metabolomics, highlighting the most used techniques in each case and its current and future applications in human health and disease.
Original language | English |
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Title of host publication | Principles of translational science in medicine |
Subtitle of host publication | from bench to bedside, third edition |
Editors | Martin Wehling |
Publisher | Elsevier |
Pages | 33-48 |
Number of pages | 16 |
Edition | 3 |
ISBN (Electronic) | 9780128204931 |
ISBN (Print) | 9780323999625 |
DOIs | |
Publication status | Published - 1 Jan 2021 |
Keywords
- Biomarkers
- Metabolomics
- Omics technologies
- Proteomics
- Transcriptomics