TY - JOUR
T1 - The role of inflammation in diabetic cardiomyopathy
AU - Nunes, Sara
AU - Soares, Edna
AU - Pereira, Frederico
AU - Reis, Flávio
PY - 2012/7/20
Y1 - 2012/7/20
N2 - Type 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents a serious public health problem, with high rates of mortality and morbidity worldwide. T2DM etiology is complex and multifactorial and is associated with several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) is viewed as a specific cardiomyopathy and defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes. T2DM has long been classified as an inflammatory disease and recent studies have identified the importance of the inflammatory process in the development and progression of heart failure. In this review, the authors outline the main mechanisms underlying the potential contribution of the inflammatory process in the development and evolution of DCM. In addition, potential therapeutic strategies against inflammation of DCM are discussed.
AB - Type 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents a serious public health problem, with high rates of mortality and morbidity worldwide. T2DM etiology is complex and multifactorial and is associated with several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) is viewed as a specific cardiomyopathy and defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes. T2DM has long been classified as an inflammatory disease and recent studies have identified the importance of the inflammatory process in the development and progression of heart failure. In this review, the authors outline the main mechanisms underlying the potential contribution of the inflammatory process in the development and evolution of DCM. In addition, potential therapeutic strategies against inflammation of DCM are discussed.
KW - Inflammation
KW - Inflammatory process
KW - Myocardium
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84864849181&partnerID=8YFLogxK
U2 - 10.2147/IJICMR.S21679
DO - 10.2147/IJICMR.S21679
M3 - Review article
AN - SCOPUS:84864849181
SN - 1179-139X
VL - 4
SP - 59
EP - 73
JO - International Journal of Interferon, Cytokine and Mediator Research
JF - International Journal of Interferon, Cytokine and Mediator Research
IS - 1
ER -
