TY - JOUR
T1 - The role of muscle in the susceptibility and progression of axial Spondyloarthritis
T2 - The MyoSpA study protocol
AU - Sardoo, A. M.
AU - Neto, A.
AU - Torres, R. Pinheiro
AU - Rodrigues-Manica, S.
AU - Domingues, L.
AU - Crespo, C. Lage
AU - Lagoas-Gomes, J.
AU - Mascarenhas, V.
AU - Mendes, C. S.
AU - Galzerano, A.
AU - de Almeida, S. Fernandes
AU - Sepriano, A.
AU - Ramiro, S.
AU - Masi, A. T.
AU - Nair, K.
AU - Costa, J.
AU - Alexandre, B. M.
AU - Vassilevskaia, T.
AU - Cunha, C. V.
AU - Sobral, D.
AU - Branco, J. C.
AU - Gomes-Alves, P.
AU - Pimentel-Santos, F. M.
N1 - Funding Information:
This study was supported by iNOVA4Health (consortia to create a multidisdiplinary/translational network at the NOVA University, Lisbon, Portugal) and Portuguese Society of Rheumatology grants.
Publisher Copyright:
© 2021, Acta Reumatologica Portuguesa. All Rights Reserved.
PY - 2021
Y1 - 2021
N2 - Background: Axial Spondyloarthritis (axSpA) is a chronic, inflammatory rheumatic disease that affectsthe axial skeleton, causing pain, stiffness, and fatigue.Genetics and environmental factors such as microbiotaand microtrauma are known causes of disease susceptibilityand progression. Murine models of axSpAfound a decisive role for biomechanical stress as an inducerof enthesitis and new bone formation. Here, wehypothesize that muscle properties in axSpA patientsare compromised and influenced by genetic background.Objectives: To improve our current knowledge of axSpAphysiopathology, we aim to characterize axial andperipheral muscle properties and identify genetic andprotein biomarker that might explain such properties.Methods: A cross-sectional study will be conducted on48 participants aged 18-50 years old, involving patientswith axSpA (according to ASAS classification criteria, symptoms duration < 10 years) and healthy controlsmatched by gender, age, and levels of physical activity.We will collect epidemiological and clinical data andperform a detailed, whole body and segmental, myofascialcharacterization (focusing on multifidus, brachioradialisand the gastrocnemius lateralis) concerning:a) Physical Properties (stiffness, tone and elasticity),assessed by MyotonPRO®; b) Strength, by a dynamometer;c) Mass, by bioimpedance; d) Performancethrough gait speed and 60-second sit-to-stand test; e)Histological and cellular/ molecular characterizationthrough ultrasound-guided biopsies of multifidus muscle;f) Magnetic Resonance Imaging (MRI) characterizationof paravertebral muscles. Furthermore, we willperform an integrated transcriptomics and proteomicsanalysis of peripheral blood samples.Discussion: The innovative and multidisciplinary approachesof this project rely on the elucidation of myofascialphysical properties in axSpA and also on the establishmentof a biological signature that relates tospecific muscle properties.
AB - Background: Axial Spondyloarthritis (axSpA) is a chronic, inflammatory rheumatic disease that affectsthe axial skeleton, causing pain, stiffness, and fatigue.Genetics and environmental factors such as microbiotaand microtrauma are known causes of disease susceptibilityand progression. Murine models of axSpAfound a decisive role for biomechanical stress as an inducerof enthesitis and new bone formation. Here, wehypothesize that muscle properties in axSpA patientsare compromised and influenced by genetic background.Objectives: To improve our current knowledge of axSpAphysiopathology, we aim to characterize axial andperipheral muscle properties and identify genetic andprotein biomarker that might explain such properties.Methods: A cross-sectional study will be conducted on48 participants aged 18-50 years old, involving patientswith axSpA (according to ASAS classification criteria, symptoms duration < 10 years) and healthy controlsmatched by gender, age, and levels of physical activity.We will collect epidemiological and clinical data andperform a detailed, whole body and segmental, myofascialcharacterization (focusing on multifidus, brachioradialisand the gastrocnemius lateralis) concerning:a) Physical Properties (stiffness, tone and elasticity),assessed by MyotonPRO®; b) Strength, by a dynamometer;c) Mass, by bioimpedance; d) Performancethrough gait speed and 60-second sit-to-stand test; e)Histological and cellular/ molecular characterizationthrough ultrasound-guided biopsies of multifidus muscle;f) Magnetic Resonance Imaging (MRI) characterizationof paravertebral muscles. Furthermore, we willperform an integrated transcriptomics and proteomicsanalysis of peripheral blood samples.Discussion: The innovative and multidisciplinary approachesof this project rely on the elucidation of myofascialphysical properties in axSpA and also on the establishmentof a biological signature that relates tospecific muscle properties.
KW - Biomarkers
KW - Muscle
KW - Precision medicine
KW - Spondyloarthritis
UR - http://www.scopus.com/inward/record.url?scp=85123051953&partnerID=8YFLogxK
M3 - Article
C2 - 34962249
AN - SCOPUS:85123051953
SN - 0303-464X
VL - 46
SP - 342
EP - 349
JO - Acta Reumatologica Portuguesa
JF - Acta Reumatologica Portuguesa
IS - 4
ER -