The role of natural-based biomaterials in advanced therapies for autoimmune diseases

Helena Ferreira; Joana F. Fangueiro; Nuno M. Neves

doi:10.1007/978-981-13-0947-2_8

The role of natural-based biomaterials in advanced therapies for autoimmune diseases

Helena Ferreira^*
, Joana F. Fangueiro
, Nuno M. Neves

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

Autoimmune diseases (ADs) constitute a heterogeneous group of more than 100 pathophysiological conditions in which an immune response against the self is observed. The incidence and prevalence of these chronic diseases are increasing with inherently high social and economic impacts. The currently available therapies generally focus on reducing the activity of the immune system and, therefore, can present severe side effects such as enhanced patient susceptibility to opportunistic infections. Advanced therapies emerged as promising treatments and with real curative potential for ADs. Additionally, the use of natural polymers to engineer gene therapies, cell therapies and/or tissue-engineered medicinal products presents specific advantages. Natural polymers present higher affinity with biological systems than synthetic polymers, and frequently have a chemical structure and motifs similar to those existing in the extracellular matrix of the tissues. They also have good biological performance, making them very strong candidates for advanced therapy medicinal products. This review discusses the therapeutic advances and provides demonstrative examples of the role of natural-based biomaterials for the development of advanced therapies for ADs.

Original language	English
Title of host publication	Advances in experimental medicine and biology
Editors	Heung Jae Chun, Kwideok Park, Chun-Ho Kim, Gilson Khang
Publisher	Springer New York LLC
Pages	127-146
Number of pages	20
ISBN (Electronic)	9789811309472
ISBN (Print)	9789811345371, 9789811309465
DOIs	https://doi.org/10.1007/978-981-13-0947-2_8
Publication status	Published - 2018
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1077
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Advanced therapies
Autoimmune diseases
Cell therapy
Gene therapy
Natural-based biomaterials
Stem cells

Access to Document

10.1007/978-981-13-0947-2_8

Cite this

Ferreira, H., Fangueiro, J. F., & Neves, N. M. (2018). The role of natural-based biomaterials in advanced therapies for autoimmune diseases. In H. J. Chun, K. Park, C.-H. Kim, & G. Khang (Eds.), Advances in experimental medicine and biology (pp. 127-146). (Advances in Experimental Medicine and Biology; Vol. 1077). Springer New York LLC. https://doi.org/10.1007/978-981-13-0947-2_8

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title = "The role of natural-based biomaterials in advanced therapies for autoimmune diseases",

abstract = "Autoimmune diseases (ADs) constitute a heterogeneous group of more than 100 pathophysiological conditions in which an immune response against the self is observed. The incidence and prevalence of these chronic diseases are increasing with inherently high social and economic impacts. The currently available therapies generally focus on reducing the activity of the immune system and, therefore, can present severe side effects such as enhanced patient susceptibility to opportunistic infections. Advanced therapies emerged as promising treatments and with real curative potential for ADs. Additionally, the use of natural polymers to engineer gene therapies, cell therapies and/or tissue-engineered medicinal products presents specific advantages. Natural polymers present higher affinity with biological systems than synthetic polymers, and frequently have a chemical structure and motifs similar to those existing in the extracellular matrix of the tissues. They also have good biological performance, making them very strong candidates for advanced therapy medicinal products. This review discusses the therapeutic advances and provides demonstrative examples of the role of natural-based biomaterials for the development of advanced therapies for ADs.",

keywords = "Advanced therapies, Autoimmune diseases, Cell therapy, Gene therapy, Natural-based biomaterials, Stem cells",

author = "Helena Ferreira and Fangueiro, \{Joana F.\} and Neves, \{Nuno M.\}",

note = "Funding Information: Acknowledgements The authors wish to acknowledge the Programa Operacional Norte 2020 under the research project FROnTHERA (NORTE-01-0145-FEDER-000023) and the Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia do Minist{\'e}rio da Ci{\^e}ncia e Tecnologia (FCT, Portugal) under the research project SPARTAN (PTDC/CTM-BIO/4388/2014). Publisher Copyright: {\textcopyright} 2018, Springer Nature Singapore Pte Ltd.",

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doi = "10.1007/978-981-13-0947-2\_8",

language = "English",

isbn = "9789811345371",

series = "Advances in Experimental Medicine and Biology",

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The role of natural-based biomaterials in advanced therapies for autoimmune diseases. / Ferreira, Helena; Fangueiro, Joana F.; Neves, Nuno M.
Advances in experimental medicine and biology. ed. / Heung Jae Chun; Kwideok Park; Chun-Ho Kim; Gilson Khang. Springer New York LLC, 2018. p. 127-146 (Advances in Experimental Medicine and Biology; Vol. 1077).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

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AU - Fangueiro, Joana F.

AU - Neves, Nuno M.

N1 - Funding Information: Acknowledgements The authors wish to acknowledge the Programa Operacional Norte 2020 under the research project FROnTHERA (NORTE-01-0145-FEDER-000023) and the Fundação para a Ciência e Tecnologia do Ministério da Ciência e Tecnologia (FCT, Portugal) under the research project SPARTAN (PTDC/CTM-BIO/4388/2014). Publisher Copyright: © 2018, Springer Nature Singapore Pte Ltd.

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AB - Autoimmune diseases (ADs) constitute a heterogeneous group of more than 100 pathophysiological conditions in which an immune response against the self is observed. The incidence and prevalence of these chronic diseases are increasing with inherently high social and economic impacts. The currently available therapies generally focus on reducing the activity of the immune system and, therefore, can present severe side effects such as enhanced patient susceptibility to opportunistic infections. Advanced therapies emerged as promising treatments and with real curative potential for ADs. Additionally, the use of natural polymers to engineer gene therapies, cell therapies and/or tissue-engineered medicinal products presents specific advantages. Natural polymers present higher affinity with biological systems than synthetic polymers, and frequently have a chemical structure and motifs similar to those existing in the extracellular matrix of the tissues. They also have good biological performance, making them very strong candidates for advanced therapy medicinal products. This review discusses the therapeutic advances and provides demonstrative examples of the role of natural-based biomaterials for the development of advanced therapies for ADs.

KW - Advanced therapies

KW - Autoimmune diseases

KW - Cell therapy

KW - Gene therapy

KW - Natural-based biomaterials

KW - Stem cells

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BT - Advances in experimental medicine and biology

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A2 - Khang, Gilson

PB - Springer New York LLC

ER -

The role of natural-based biomaterials in advanced therapies for autoimmune diseases

Abstract

Publication series

UN SDGs

Keywords

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