Therapeutic and nutraceutical potential of rosmarinic acid—cytoprotective properties and pharmacokinetic profile

Sara Nunes, Ana Raquel Madureira, Débora Campos, Bruno Sarmento, Ana Maria Gomes, Manuela Pintado, Flávio Reis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

104 Citations (Scopus)


Rosmarinic acid (RA) is a natural polyphenolic antioxidant derived from many common herbal plants. This compound displays several important biological properties, including anti-inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and chemopreventive properties. The importance of its activities and its possible application in processed foods as a natural antioxidant has reached a new interest levels in recent years. The health effects of this polyphenol depend greatly on both its intakes and bioavailability. This review focuses on the importance of RA as a dietary supplement, and summarizes its pharmacokinetics and metabolism, including the factors that limit its oral bioavailability which leads to a lower therapeutic action. Further experimental investigations are needed to optimize and enhance the oral bioavailability of this natural compound which consequently will help increasing therapeutic efficacy of RA in vivo.

Original languageEnglish
Pages (from-to)1799-1806
Number of pages8
JournalCritical Reviews in Food Science and Nutrition
Issue number9
Publication statusPublished - 13 Jun 2017


  • Cytoprotective properties
  • In vivo models
  • Nutraceutical
  • Pharmacokinetic profile
  • Rosmarinic acid
  • Therapeutic


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