Three minimal sequences found in Ebola virus genomes and absent from human DNA

Raquel M. Silva; Diogo Pratas; Luísa Castro; Armando J. Pinho; Paulo J. S. G. Ferreira

doi:10.1093/bioinformatics/btv189

Three minimal sequences found in Ebola virus genomes and absent from human DNA

Raquel M. Silva^*, Diogo Pratas, Luísa Castro, Armando J. Pinho, Paulo J. S. G. Ferreira

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Motivation: Ebola virus causes high mortality hemorrhagic fevers, with more than 25 000 cases and 10000 deaths in the current outbreak. Only experimental therapies are available, thus, novel diagnosis tools and druggable targets are needed. Results: Analysis of Ebola virus genomes from the current outbreak reveals the presence of short DNA sequences that appear nowhere in the human genome. We identify the shortest such sequences with lengths between 12 and 14. Only three absent sequences of length 12 exist and they consistently appear at the same location on two of the Ebola virus proteins, in all Ebola virus genomes, but nowhere in the human genome. The alignment-free method used is able to identify pathogen-specific signatures for quick and precise action against infectious agents, of which the current Ebola virus outbreak provides a compelling example.

Original language	English
Pages (from-to)	2421-2425
Number of pages	5
Journal	Bioinformatics
Volume	31
Issue number	15
DOIs	https://doi.org/10.1093/bioinformatics/btv189
Publication status	Published - 1 Aug 2015
Externally published	Yes

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10.1093/bioinformatics/btv189Licence: CC BY-NC

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Three minimal sequences found in Ebola virus genomes and absent from human DNA

Abstract

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