Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections

Daniela Machado, Carlos Gaspar, Ana Palmeira-de-Oliveira, Carlos Cavaleiro, Lígia Salgueiro, José Martinez-de-Oliveira, Nuno Cerca*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Aim: To evaluate the antibacterial activity of Thymbra capitata essential oil and its main compound, carvacrol, against Gardnerella vaginalis grown planktonically and as biofilms, and its effect of vaginal lactobacilli. Materials & methods: Minimal inhibitory concentration, minimal lethal concentration determination and flow cytometry analysis were used to assess the antibacterial effect against planktonic cells. Antibiofilm activity was measured through quantification of biomass and visualization of biofilm structure by confocal laser scanning microscopy. Results: T. capitata essential oil and carvacrol exhibited a potent antibacterial activity against G. vaginalis cells. Antibiofilm activity was more evident with the essential oil than carvacrol. Furthermore, vaginal lactobacilli were significantly more tolerant to the essential oil. Conclusion: T. capitata essential oil stands up as a promising therapeutic agent against G. vaginalis biofilm-related infections.
Original languageEnglish
Pages (from-to)407-416
Number of pages10
JournalFuture Microbiology
Volume12
Issue number5
DOIs
Publication statusPublished - Apr 2017
Externally publishedYes

Keywords

  • Bacterial vaginosis
  • Biofilms
  • Carvacrol
  • Gardnerella vaginalis
  • Lactobacilli
  • Thymbra capitata essential oil

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