Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance

Peter J. Vikesland; Amy Pruden; Pedro J. J. Alvarez; Diana Aga; Helmut Bürgmann; Xiang Dong Li; Célia M. Manaia; Indumathi Nambi; Krista Wigginton; Tong Zhang; Yong Guan Zhu

doi:10.1021/acs.est.7b03623

Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance

Peter J. Vikesland^*, Amy Pruden, Pedro J. J. Alvarez, Diana Aga, Helmut Bürgmann, Xiang Dong Li, Célia M. Manaia, Indumathi Nambi, Krista Wigginton, Tong Zhang, Yong Guan Zhu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

281 Citations (Scopus)

Abstract

Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.

Original language	English
Pages (from-to)	13061-13069
Number of pages	9
Journal	Environmental Science and Technology
Volume	51
Issue number	22
DOIs	https://doi.org/10.1021/acs.est.7b03623
Publication status	Published - 21 Nov 2017

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10.1021/acs.est.7b03623

http://hdl.handle.net/10400.14/25718

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title = "Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance",

abstract = "Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.",

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AU - Vikesland, Peter J.

AU - Pruden, Amy

AU - Alvarez, Pedro J. J.

AU - Aga, Diana

AU - Bürgmann, Helmut

AU - Li, Xiang Dong

AU - Manaia, Célia M.

AU - Nambi, Indumathi

AU - Wigginton, Krista

AU - Zhang, Tong

AU - Zhu, Yong Guan

PY - 2017/11/21

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AB - Antibiotic resistance is a pervasive global health threat. To combat the spread of resistance, it is necessary to consider all possible sources and understand the pathways and mechanisms by which resistance disseminates. Best management practices are urgently needed to provide barriers to the spread of resistance and maximize the lifespan of antibiotics as a precious resource. Herein we advise upon the need for coordinated national and international strategies, highlighting three essential components: (1) Monitoring, (2) Risk Assessment, and (3) Mitigation of antibiotic resistance. Central to all three components is What exactly to monitor, assess, and mitigate? We address this question within an environmental framework, drawing from fundamental microbial ecological processes driving the spread of resistance.

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Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance

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