Toxicity of resin-matrix cements in contact with fibroblast or mesenchymal cells

Marta Martinez-Gonzalez, Rita C. Fidalgo-Pereira, Orlanda Torres, Filipe Silva, Bruno Henriques, Mutlu Özcan, Júlio C.M. Souza*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The main aim of this study was to perform an integrative review on the toxic effects of resin-matrix cements and their products in contact with fibroblasts or mesenchymal cells. A bibliographic search was performed on PubMed using the following search terms: “cytotoxicity” AND “fibroblast” OR “epithelial” OR “mesenchymal” AND “polymerization” OR “degree of conversion” OR “methacrylate” OR “monomer” AND “resin cement” OR “resin-based cement”. The initial search in the available database yielded a total of 277 articles of which 21 articles were included in this review. A decrease in the viability of mouse fibroblasts ranged between 13 and 15% that was recorded for different resin-matrix cements after light curing exposure for 20 s. The viability of human fibroblasts was recorded at 83.11% after light curing for 20 s that increased up to 90.9% after light curing exposure for 40 s. Most of the studies linked the highest toxicity levels when the cells were in contact with Bis-GMA followed by UDMA, TEGDMA and HEMA. Resin-matrix cements cause a cytotoxic reaction when in contact with fibroblasts or mesenchymal cells due to the release of monomers from the polymeric matrix. The amount of monomers released from the resin matrix and their cytotoxicity depends on the polymerization parameters.

Original languageEnglish
JournalOdontology
DOIs
Publication statusAccepted/In press - 2022

Keywords

  • Cytotoxicity
  • Degree of conversion
  • Fibroblast
  • Polymerization
  • Resin cement

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