Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots

Ana Sofia Sousa; André Mayer; Celso Reis; Maria Manuela Pintado; Ezequiel R. Coscueta

Abstract

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.

Original language	English
Pages	1-3
Number of pages	3
Publication status	Published - Jul 2025
Event	CRS 2025 Annual Meeting & Exposition: Next-Generation Delivery Innovations - Philadelphia, PA, United States Duration: 14 Jul 2025 → 18 Jul 2025 https://www.controlledreleasesociety.org/events/crs-2025-annual-meeting-and-exposition

Conference

Conference	CRS 2025 Annual Meeting & Exposition
Abbreviated title	CRS 2025
Country/Territory	United States
City	Philadelphia, PA
Period	14/07/25 → 18/07/25
Internet address	https://www.controlledreleasesociety.org/events/crs-2025-annual-meeting-and-exposition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

http://hdl.handle.net/10400.14/56741Licence: Unspecified

Embargoed Document

138955143
Accepted author manuscript, 365 KB
Licence: Unspecified
Embargo ends: 18/07/26

Transforming Healthcare: Treatment of Inflammatory Bowel Disease with Biocatalytic Nanobots
Sousa, A. S. D. S. (Speaker), Mayer, A. D. N. D. S. (Speaker), Reis, C. (Speaker), Pintado, M. M. (Speaker) & Coscueta, E. (Speaker)
17 Jul 2025
Activity: Talk or presentation › Oral presentation

CBQF - Centre for Biotecnology and Fine Chemistry: UID/50016/2025. Pluriannual 2025-2029
Pintado, M. M. (PI)
1/01/25 → 31/12/29
Project: Research
microHEROS: Microbots for gastrointestinal health: Targeting Helicobacter pylori infection and ROS imbalance
Coscueta, E. (PI)
1/11/24 → 31/10/30
Project: Research
gBiOT: Nutraceutical biopolymeric-biocatalytic microbot against gut inflammatory disorders
Coscueta, E. (PI), Pintado, M. M. (CoPI), Machado, M. (Researcher), Correia Coelho, M. I. (Researcher), Rodrigues, P. M. (Researcher), Sousa, A. S. D. S. (Researcher), Sousa, C. (Researcher), Magalhães, A. (Researcher) & Santos Matos, R. D. (Researcher)
Fundação para a Ciência e a Tecnologia
1/03/23 → 28/02/27
Project: Research

CBQF researchers as invited speakers at the world’s leading conference on drug delivery technologies
Coscueta, E. & Sousa, A. S. D. S.
28/07/25
1 item of Media coverage
Press/Media

Desenvolvimento de um nanobot com propulsão biocatalítica e neutralizante das espécies reativas de oxigénio co cólon inflamado
Mayer, A. D. N. D. S. (Student), Coscueta, E. R. (Supervisor) & Pintado, M. M. E. (Co-Supervisor), 17 Dec 2024
Student thesis: Master's Thesis

Cite this

@conference{c51ef1a96cb042d9932bfd0e93574d6e,

title = "Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots",

abstract = "Inflammatory bowel disease (IBD), including Crohn{\textquoteright}s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract. ",

author = "Sousa, \{Ana Sofia\} and Andr{\'e} Mayer and Celso Reis and Pintado, \{Maria Manuela\} and Coscueta, \{Ezequiel R.\}",

year = "2025",

month = jul,

language = "English",

pages = "1--3",

note = "CRS 2025 Annual Meeting \& Exposition : Next-Generation Delivery Innovations, CRS 2025 ; Conference date: 14-07-2025 Through 18-07-2025",

url = "https://www.controlledreleasesociety.org/events/crs-2025-annual-meeting-and-exposition",

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TY - CONF

T1 - Transforming healthcare

T2 - CRS 2025 Annual Meeting & Exposition

AU - Sousa, Ana Sofia

AU - Mayer, André

AU - Reis, Celso

AU - Pintado, Maria Manuela

AU - Coscueta, Ezequiel R.

PY - 2025/7

Y1 - 2025/7

N2 - Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.

AB - Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, affects over seven million individuals globally, presenting significant healthcare and economic challenges (1). The inflamed gut microenvironment is characterized by excessive reactive oxygen species (ROS), which exacerbates mucosal damage (2). To address these limitations, a modular polymeric nanobot (NB) system is under development, with each module offering distinct functionalities. This study focuses on designing the NB core to mitigate oxidative stress and encapsulate bioactive compounds, laying the groundwork for subsequent modules that will enhance stability, navigation, and targeted delivery along the gastrointestinal (GI) tract.

M3 - Abstract

SP - 1

EP - 3

Y2 - 14 July 2025 through 18 July 2025

ER -

Transforming healthcare: treatment of inflammatory bowel disease with Bbocatalytic nanobots

Abstract

Conference

UN SDGs

Access to Document

Embargoed Document

Fingerprint

Activities

Transforming Healthcare: Treatment of Inflammatory Bowel Disease with Biocatalytic Nanobots

Projects

CBQF - Centre for Biotecnology and Fine Chemistry: UID/50016/2025. Pluriannual 2025-2029

microHEROS: Microbots for gastrointestinal health: Targeting Helicobacter pylori infection and ROS imbalance

gBiOT: Nutraceutical biopolymeric-biocatalytic microbot against gut inflammatory disorders

Press/Media

CBQF researchers as invited speakers at the world’s leading conference on drug delivery technologies

Student theses

Desenvolvimento de um nanobot com propulsão biocatalítica e neutralizante das espécies reativas de oxigénio co cólon inflamado

Cite this