TY - JOUR
T1 - Ulcerative colitis as a progressive disease
T2 - The forgotten evidence
AU - Torres, Joana
AU - Billioud, Vincent
AU - Sachar, David B.
AU - Peyrin-Biroulet, Laurent
AU - Colombel, Jean Fred́éric
PY - 2012/7
Y1 - 2012/7
N2 - In the management of Crohn's disease, earlier aggressive treatment is becoming accepted as a strategy to prevent or retard progression to irreversible bowel damage. It is not yet clear, however, if this same concept should be applied to ulcerative colitis. Hence, we review herein the long-term structural and functional consequences of this latter disease. Disease progression in ulcerative colitis takes six principal forms: proximal extension, stricturing, pseudopolyposis, dysmotility, anorectal dysfunction, and impaired permeability. The precise incidence of these complications and the ability of earlier, more aggressive treatment to prevent them have yet to be determined.
AB - In the management of Crohn's disease, earlier aggressive treatment is becoming accepted as a strategy to prevent or retard progression to irreversible bowel damage. It is not yet clear, however, if this same concept should be applied to ulcerative colitis. Hence, we review herein the long-term structural and functional consequences of this latter disease. Disease progression in ulcerative colitis takes six principal forms: proximal extension, stricturing, pseudopolyposis, dysmotility, anorectal dysfunction, and impaired permeability. The precise incidence of these complications and the ability of earlier, more aggressive treatment to prevent them have yet to be determined.
KW - Bowel damage
KW - Complications of IBD
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=84862196654&partnerID=8YFLogxK
U2 - 10.1002/ibd.22839
DO - 10.1002/ibd.22839
M3 - Review article
C2 - 22162423
AN - SCOPUS:84862196654
SN - 1078-0998
VL - 18
SP - 1356
EP - 1363
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
IS - 7
ER -