Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells

Ana T. P. C. Gomes; M. Graça P. M. S. Neves; Rosa Fernandes; Carlos F. Ribeiro; José A. S. Cavaleiro; Nuno M. M. Moura

doi:10.3390/molecules26175312

Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells

Ana T. P. C. Gomes^*, M. Graça P. M. S. Neves, Rosa Fernandes, Carlos F. Ribeiro, José A. S. Cavaleiro, Nuno M. M. Moura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.

Original language	English
Article number	5312
Number of pages	17
Journal	Molecules
Volume	26
Issue number	17
DOIs	https://doi.org/10.3390/molecules26175312
Publication status	Published - 1 Sept 2021

Keywords

Benzoporphyrin
Cancer
Photodynamic therapy
Photosensitizer
Platinum complexes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules26175312Licence: CC BY

38169719Final published version, 2.09 MBLicence: CC BY

http://hdl.handle.net/10400.14/34878Licence: CC BY

Cite this

@article{7ff0c021eacd4ee786113ab0bcdc9e6b,

title = "Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells",

abstract = "In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs{\textquoteright} derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells{\textquoteright} viability. This creates an avenue to further studies related to bladder cancer cells.",

keywords = "Benzoporphyrin, Cancer, Photodynamic therapy, Photosensitizer, Platinum complexes",

author = "Gomes, {Ana T. P. C.} and Neves, {M. Gra{\c c}a P. M. S.} and Rosa Fernandes and Ribeiro, {Carlos F.} and Cavaleiro, {Jos{\'e} A. S.} and Moura, {Nuno M. M.}",

note = "Funding Information: Funding: Thanks are due to the University of Aveiro and FCT/MCT for the financial support for the LAQV-REQUIMTE (UIDB/50006/2020), CIBB (UIDB/04539/2020, UIDP/04539/2020), and CNC.IBILI (UID/NEU/04539/2019) research units through national funds within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. NMM Moura thanks his research contract (CDL-CTTRI-048-88-ARH/2018), which is funded by national funds (OE), through FCT—Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of the article 23 of the Law Decree 57/2016 of 29August, changed by Law 57/2017 of 19 July. Funding Information: Thanks are due to the University of Aveiro and FCT/MCT for the financial support for the LAQV-REQUIMTE (UIDB/50006/2020), CIBB (UIDB/04539/2020, UIDP/04539/2020), and CNC.IBILI (UID/NEU/04539/2019) research units through national funds within the PT2020 Part-nership Agreement, and to the Portuguese NMR Network. NMM Moura thanks his research contract (CDL-CTTRI-048-88-ARH/2018), which is funded by national funds (OE), through FCT?Funda??o para a Ci?ncia e a Tecnologia, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of the article 23 of the Law Decree 57/2016 of 29August, changed by Law 57/2017 of 19 July. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

day = "1",

doi = "10.3390/molecules26175312",

language = "English",

volume = "26",

journal = "Molecules",

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T1 - Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells

AU - Gomes, Ana T. P. C.

AU - Neves, M. Graça P. M. S.

AU - Fernandes, Rosa

AU - Ribeiro, Carlos F.

AU - Cavaleiro, José A. S.

AU - Moura, Nuno M. M.

N1 - Funding Information: Funding: Thanks are due to the University of Aveiro and FCT/MCT for the financial support for the LAQV-REQUIMTE (UIDB/50006/2020), CIBB (UIDB/04539/2020, UIDP/04539/2020), and CNC.IBILI (UID/NEU/04539/2019) research units through national funds within the PT2020 Partnership Agreement, and to the Portuguese NMR Network. NMM Moura thanks his research contract (CDL-CTTRI-048-88-ARH/2018), which is funded by national funds (OE), through FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of the article 23 of the Law Decree 57/2016 of 29August, changed by Law 57/2017 of 19 July. Funding Information: Thanks are due to the University of Aveiro and FCT/MCT for the financial support for the LAQV-REQUIMTE (UIDB/50006/2020), CIBB (UIDB/04539/2020, UIDP/04539/2020), and CNC.IBILI (UID/NEU/04539/2019) research units through national funds within the PT2020 Part-nership Agreement, and to the Portuguese NMR Network. NMM Moura thanks his research contract (CDL-CTTRI-048-88-ARH/2018), which is funded by national funds (OE), through FCT?Funda??o para a Ci?ncia e a Tecnologia, I.P., in the scope of the framework contract foreseen in numbers 4, 5, and 6 of the article 23 of the Law Decree 57/2016 of 29August, changed by Law 57/2017 of 19 July. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.

AB - In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.

KW - Benzoporphyrin

KW - Cancer

KW - Photodynamic therapy

KW - Photosensitizer

KW - Platinum complexes

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U2 - 10.3390/molecules26175312

DO - 10.3390/molecules26175312

M3 - Article

C2 - 34500746

AN - SCOPUS:85114375167

SN - 1420-3049

VL - 26

JO - Molecules

JF - Molecules

IS - 17

M1 - 5312

ER -

Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells

Abstract

Keywords

UN SDGs

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CEEC Institucional 2018 - CIIS: Infeções orais crónicas: diagnóstico não invasivo e novas terapias

CIIS: Center for Interdisciplinary Research in Health

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Unraveling the photodynamic activity of cationic benzoporphyrin-based photosensitizers against bladder cancer cells

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

CEEC Institucional 2018 - CIIS: Infeções orais crónicas: diagnóstico não invasivo e novas terapias

CIIS: Center for Interdisciplinary Research in Health

Cite this