Unveiling the functions of NMRK1- and NMRK2-mediated NAD synthesis in neuronal cells

Diogo Neves; Sandra I. Vieira; Brian J. Goodfellow; Ramiro Almeida; Raquel M. Silva

Unveiling the functions of NMRK1- and NMRK2-mediated NAD synthesis in neuronal cells

Diogo Neves^*
, Sandra I. Vieira
, Brian J. Goodfellow
, Ramiro Almeida
, Raquel M. Silva

^*Corresponding author for this work

Research output: Contribution to conference › Poster

Abstract

Nicotinamide adenine dinucleotide (NAD) is critical for energy production and cell metabolism. It acts both as a coenzyme for oxidation-reduction reactions that culminate in ATP synthesis and as a substrate for NAD-consuming enzymes which include sirtuins, ADPribose transferases (ARTs), poly(ADP-ribose) polymerases (PARPs) and cADP-ribose synthases. NAD biosynthesis in mammals is supported by several precursors and it was shown that one of those, Nicotinamide Riboside (NamR), is used for NAD production in neurons1 . Moreover, NAD was reported to be involved in tissue differentiation (e.g. skeletal muscle and adipose tissue)2,3 and to protect against physical and excitotoxic nerve injury4

Original language	English
Publication status	Published - 2 Jul 2018
Externally published	Yes
Event	Simpósio de pós-graduação do iBiMED - iBiMED, Aveiro, Portugal Duration: 2 Jul 2018 → 2 Jul 2018 Conference number: IV

Other

Other	Simpósio de pós-graduação do iBiMED
Country/Territory	Portugal
City	Aveiro
Period	2/07/18 → 2/07/18

Cite this

@conference{83e0a71a1fa349a8b29a69c3cc605970,

title = "Unveiling the functions of NMRK1- and NMRK2-mediated NAD synthesis in neuronal cells",

abstract = "Nicotinamide adenine dinucleotide (NAD) is critical for energy production and cell metabolism. It acts both as a coenzyme for oxidation-reduction reactions that culminate in ATP synthesis and as a substrate for NAD-consuming enzymes which include sirtuins, ADPribose transferases (ARTs), poly(ADP-ribose) polymerases (PARPs) and cADP-ribose synthases. NAD biosynthesis in mammals is supported by several precursors and it was shown that one of those, Nicotinamide Riboside (NamR), is used for NAD production in neurons1 . Moreover, NAD was reported to be involved in tissue differentiation (e.g. skeletal muscle and adipose tissue)2,3 and to protect against physical and excitotoxic nerve injury4",

author = "Diogo Neves and Vieira, \{Sandra I.\} and Goodfellow, \{Brian J.\} and Ramiro Almeida and Silva, \{Raquel M.\}",

year = "2018",

month = jul,

day = "2",

language = "English",

note = "Simp{\'o}sio de p{\'o}s-gradua{\c c}{\~a}o do iBiMED ; Conference date: 02-07-2018 Through 02-07-2018",

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TY - CONF

T1 - Unveiling the functions of NMRK1- and NMRK2-mediated NAD synthesis in neuronal cells

AU - Neves, Diogo

AU - Vieira, Sandra I.

AU - Goodfellow, Brian J.

AU - Almeida, Ramiro

AU - Silva, Raquel M.

N1 - Conference code: IV

PY - 2018/7/2

Y1 - 2018/7/2

N2 - Nicotinamide adenine dinucleotide (NAD) is critical for energy production and cell metabolism. It acts both as a coenzyme for oxidation-reduction reactions that culminate in ATP synthesis and as a substrate for NAD-consuming enzymes which include sirtuins, ADPribose transferases (ARTs), poly(ADP-ribose) polymerases (PARPs) and cADP-ribose synthases. NAD biosynthesis in mammals is supported by several precursors and it was shown that one of those, Nicotinamide Riboside (NamR), is used for NAD production in neurons1 . Moreover, NAD was reported to be involved in tissue differentiation (e.g. skeletal muscle and adipose tissue)2,3 and to protect against physical and excitotoxic nerve injury4

AB - Nicotinamide adenine dinucleotide (NAD) is critical for energy production and cell metabolism. It acts both as a coenzyme for oxidation-reduction reactions that culminate in ATP synthesis and as a substrate for NAD-consuming enzymes which include sirtuins, ADPribose transferases (ARTs), poly(ADP-ribose) polymerases (PARPs) and cADP-ribose synthases. NAD biosynthesis in mammals is supported by several precursors and it was shown that one of those, Nicotinamide Riboside (NamR), is used for NAD production in neurons1 . Moreover, NAD was reported to be involved in tissue differentiation (e.g. skeletal muscle and adipose tissue)2,3 and to protect against physical and excitotoxic nerve injury4

M3 - Poster

T2 - Simpósio de pós-graduação do iBiMED

Y2 - 2 July 2018 through 2 July 2018

ER -

Unveiling the functions of NMRK1- and NMRK2-mediated NAD synthesis in neuronal cells

Abstract

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