Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae

Eleanor R. Watkins; Bridget S. Penman; José Lourenço; Caroline O. Buckee; Martin C.J. Maiden; Sunetra Gupta

doi:10.1371/journal.ppat.1005034

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae

Eleanor R. Watkins, Bridget S. Penman, José Lourenço, Caroline O. Buckee, Martin C.J. Maiden, Sunetra Gupta^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.

Original language	English
Article number	e1005034
Journal	PLoS Pathogens
Volume	11
Issue number	7
DOIs	https://doi.org/10.1371/journal.ppat.1005034
Publication status	Published - 1 Jul 2015
Externally published	Yes

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title = "Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae",

abstract = "The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.",

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AU - Maiden, Martin C.J.

AU - Gupta, Sunetra

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Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae

Abstract

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