TY - JOUR
T1 - Vascular morphogenesis
T2 - a Wnt for every vessel?
AU - Franco, Claudio Areias
AU - Liebner, Stefan
AU - Gerhardt, Holger
N1 - Funding Information:
The authors are supported by Cancer Research UK (HG, CAF), EMBO Young Investigator Programme (HG), the Lister Institute for Preventive Medicine (HG) and the Deutsche Forschungsgemeinschaft (SFB/TR23, Excellence Cluster Cardio-Pulmonary System, ECCPS; SL). We apologize to authors of relevant work not cited because of space restrictions.
PY - 2009/10
Y1 - 2009/10
N2 - Blood vessel development requires orchestrated activities of heterogeneous endothelial cell (EC) populations to create a hierarchically branched tubular network. Endothelial heterogeneity is manifested in organ-specific endothelial differentiation and function in the mature vasculature. During sprouting angiogenesis, ECs are specified by Dll4/Notch signalling into leading tip cells and following stalk cells, which together through coordinated migration and proliferation shape the nascent vascular sprout. Wnt-signalling influences many aspects of branching tubulogenesis in various species and organ systems, often in coordination with Notch signalling. Recent advances in vascular biology highlight important roles for multiple components of the Wnt-signalling pathway in regulating cell differentiation, proliferation, survival, cell junctions and polarity. Here, we review the emerging concepts of the molecular actions of Wnt-signalling in regulating differential behaviour and/or cell functions during vascular development.
AB - Blood vessel development requires orchestrated activities of heterogeneous endothelial cell (EC) populations to create a hierarchically branched tubular network. Endothelial heterogeneity is manifested in organ-specific endothelial differentiation and function in the mature vasculature. During sprouting angiogenesis, ECs are specified by Dll4/Notch signalling into leading tip cells and following stalk cells, which together through coordinated migration and proliferation shape the nascent vascular sprout. Wnt-signalling influences many aspects of branching tubulogenesis in various species and organ systems, often in coordination with Notch signalling. Recent advances in vascular biology highlight important roles for multiple components of the Wnt-signalling pathway in regulating cell differentiation, proliferation, survival, cell junctions and polarity. Here, we review the emerging concepts of the molecular actions of Wnt-signalling in regulating differential behaviour and/or cell functions during vascular development.
UR - http://www.scopus.com/inward/record.url?scp=71849117650&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2009.09.004
DO - 10.1016/j.gde.2009.09.004
M3 - Review article
C2 - 19864126
SN - 0959-437X
VL - 19
SP - 476
EP - 483
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -