Yeast as a tool to explore cathepsin D function

H. Pereira, C. S.F. Oliveira, L. Castro, A. Preto, S. R. Chaves, M. Côrte-Real*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may constitute a therapeutic target. However, cathepsin D can have both anti-and pro-survival functions depending on its proteolytic activity, cellular context and stress stimulus. Therefore, a more detailed understanding of cathepsin D regulation and how to modulate its apoptotic functions is clearly needed. In this review, we provide an overview of the role of cathepsin D in physiological and pathological scenarios. We then focus on the opposing functions of cathepsin D in apoptosis, particularly relevant in cancer research. Emphasis is given to the role of the yeast protease Pep4p, the vacuolar counterpart of cathepsin D, in life and death. Finally, we discuss how insights from yeast cathepsin D and its role in regulated cell death can unveil novel functions of mammalian cathepsin D in apoptosis and cancer.

Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalMicrobial Cell
Volume2
Issue number7
DOIs
Publication statusPublished - Jul 2015
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Cathepsin D
  • Yeast cathepsin D
  • Yeast model

Fingerprint

Dive into the research topics of 'Yeast as a tool to explore cathepsin D function'. Together they form a unique fingerprint.

Cite this