A toxina botulínica no tratamento de distúrbios temporomandibulares

: revisão sistemática

Abstract

Introduction: The application of Botulinum Toxin (BT) in the treatment of patients with Temporomandibular Disorders (TMD) has been poorly studied. Therefore, the primary objective of this systematic review is to seek scientific evidence validating the use of BT in the treatment of TMD. Materials and Methods: The selection of studies to be included in this systematic review was conducted by 2 independent investigators according to PRISMA guidelines, the research question by the PICO acronym, and the research protocol registered in PROSPERO (CRD42023388330). The search focused on 3 databases:
PubMed/MEDLINE®, Web of Science®, and Cochrane®. The quality of the studies
was assessed using the Downs and Black checklist, and the agreement between
examiners was measured using Cohen's Kappa coefficient. Data were collected
regarding the date of the studies, the population involved (age, gender, sample size), the brand of toxin used, dosage, and application sites. The main results and conclusions of each study included in this review were analyzed comparatively. Results: Through the search in the databases, 84 articles were obtained. After excluding duplicates/triplicates, 76 articles remained. Out of the 76, selection was made based on title reading (59 articles), abstract reading (36 articles), and finally, after reading the full article, a total of 17 articles were included for this review. Three different brands of BT (BOTOX® Allergan, Dysport® IPSEN, Xeomeen® MERZ) were used with an average concentration of 100U diluted in a saline solution. The main indication for BT application is muscular pathology, and the preferred infiltration sites are the temporal and masseter muscles. Conclusion: In general, the studies allow us to conclude that the use of botulinum toxin has shown efficacy in the treatment of TMD, however, it remains a second-line treatment option.

Date of Award	26 Jul 2023
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Patrícia Fonseca (Supervisor) & Helena Salgado (Co-Supervisor)