Abordagens terapêuticas da mucosite oral induzida por tratamento anti-neoplásico na população pediátrica

: uma revisão sistemática

Abstract

Introduction: Children undergoing antineoplastic treatment manifest several side effects due to the intensity and continuity of treatments. Oral mucositis is one of the most prevalent and painful inflammatory lesions found in this population, divided into stages that are based on the clinical evolution of patients. There are several therapeutic options, such as reinforcement in oral hygiene, cryotherapy, low-intensity laser therapy and alternative medicines, even if they lack scientific support. The aim of this systematic review was to bring evidence in the management of OM. Materials and methods: This systematic review was based on the PRISMA guidelines, and a search was carried out in the PubMed/MEDLINE®, Embase and grey literature databases, namely NICE and TRIAL. According to the question of research and selection criteria, articles performed in the last 20 years, in a population under 18 years of age, who were or were exposed to antineoplastic treatment, were selected. The research and screening of the articles was carried out by two independent reviewers and the quality of the studies was evaluated through the Newscastle-Ottawa scale. Results: After combining the search terms, a total of 11693 articles were obtained, after applying the respective filters a total of 281 were obtained. A first reading of the titles and abstracts was performed resulting in 23 articles. These were analyzed by full reading, eliminating 17 articles. The remaining 6 articles were part of this systematic review. Conclusion: There are several therapies available in the prevention and treatment of OM, however, there is no conclusive evidence of its efficacy to establish accurate clinical protocols. It is concluded that, in particular, low intensity laser, palifermine and andibora demonstrated a preventive effect on the development, decrease and sometimes elimination of symptomatology.

Date of Award	19 Jul 2022
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Patrícia Nunes Correia (Supervisor) & Raquel Silva (Co-Supervisor)