Advances in periodontal regeneration using resorbable membranes

Abstract

The periodontal regeneration involves the formation of new cementum, new periodontal ligament and often alveolar bone that were previously lost. The discovery that stem cells present in the periodontal ligament which have the ability to populate the bone defect and induce formation of new cementoblasts, odontoblasts and fibroblasts and allowed to re-think the use of membranes to isolate these epithelial cells and gingival connective tissue to promote guided regeneration. This monograph aims at identifying, analyze and discuss the potential for new strategies in guided tissue regeneration using resorbable membranes when comparing with more conventional approaches. It also aims at answering several questions, such as: what are the membranes already being explored in the clinical phase and which are the onesbeing developed in the preclinical phase, as well as what are the results obtained using different types of membranes for each specific case. A bibliographic search of the literature was made taking into account research studies of materials in clinical phase of development and still in the pre-clinical phase (in vitro studies and in vivo), published in the past 5 years. Although there are already several reviews about this subject, it is important to address in a systematic way the most recent advances in order to understand which solutions are being more effective to provide the adequate treatment for periodontal conditions. The main aim is to determine the cases where resorbable membranes can be used considering the type of periodontal defects, and the most suitable membranes according to each specific case, and how to combine regenerative therapies as for example, cellular therapies, use of certain bioactive molecules, just to name a few…

Date of Award	2013
Original language	English
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Ana Leite Oliveira (Supervisor)