Anomalias dentárias após tratamento anti-neoplásico na população pediátrica

: uma revisão sistemática

Abstract

Aim: Dental anomalies are frequent in childhood cancer survivors, due to early
exposure to chemotherapy and radiotherapy, since developing odontogenic cells
are highly susceptible to anticancer treatment. Due to treatment advances, the
number of childhood cancer survivors has increased and so has the number of
dental disturbances. Early diagnosis and specialist dental care are required to
support these patients. The aim of this study is to determine the specific dental
anomalies based on the patient's age at the time of treatment and the type of
cancer treatment they received. Methods: A systematic review was performed according to the PRISMA criteria. A PICO question was established and three databases, PubMed, Web of Science and Scopus, were selected to run this research. Filters and inclusion criteria were established. Inter-rater reliability and quality assessment of the selected studies was determined. Results: A total of 2692 studies were obtained from the three electronic databases. After exclusion of duplicates and subsequent selection based on titles and abstracts, 37 studies were obtained for comprehensive reading. A variety of dental anomalies were present, particularly hypodontia and anomalies of size. Studies were subsequently analysed according to age of treatment and treatment protocol. Young age was a common risk factor, and certain drugs, such as cyclophosphamide, vincristine and anthracycline, as well as radiotherapy, were
associated with a higher number of dental anomalies. Conclusion: Dental anomalies are common side effects of childhood cancer therapy. Determining the probability of developing dental anomalies is crucial for effective prevention, treatment planning, and support. This assessment plays a vital role in helping cancer survivors achieve optimal masticatory function and orofacial aesthetics.

Date of Award	21 Jul 2023
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Patrícia Nunes Correia (Supervisor), Raquel Silva (Co-Supervisor) & Anna Moura (Co-Supervisor)