As áreas cerebrais ativadas associadas ao efeito analgésico da música em adultos com dor crónica

Abstract

Pain is an unpleasant sensation with a protective function. However, when it becomes chronic, it loses this protective function and becomes only harmful and damaging to the 30% of the world's population with this condition. The World Health Organization (WHO) recognizes the need and importance of pain control and relief. In this sense, the prescription of pharmacological therapy is the first line of treatment. However, this has associated risks such as addiction, abuse, overdose and accidental death. It is therefore important to study nonpharmacological therapies that can act as adjuvant therapy and reduce the doses of pharmacological therapy. With this in mind, a scoping review was carried out with the aim of describing the brain areas and mechanisms responsible for the analgesic effect of music in adults with chronic pain. The research question was developed according to the Joanna Briggs Institute (JBI) methodology based on the PCC mnemonic - Population, Context and Concept. The Boolean phrase was drawn up and a search was carried out in the following databases: PUBMED, CINAHL, PSYINFO, SCOPUS, WEB OF SCIENCE E MEDICALATINA. Ten articles were included in this review, four narrative reviews, five experimental studies and one pilot study. The articles present a wide variety of imaging methods, musical interventions and pain assessment methods. The results of this review suggest the involvement of the descending modulatory system, mainly the dorsolateral prefrontal cortex, the cingulate cortex, the periaqueductal gray matter and the angular circumvolution. The results also show a prevalence of activity in the left hemisphere. This work highlights the importance of further studying the brain mechanisms that underlie the effectiveness of music in reducing the perception of pain, with a view to developing non-pharmacological therapies as an adjunct to pharmacological intervention.

Date of Award	15 Dec 2023
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Rita Canaipa (Supervisor) & Manuel Luís Capelas (Co-Supervisor)