Avaliação do efeito da utilização única intra-alveolar de gel de ácido hialurónico 0,2 % vs. gel de clorohexidina 0,2 % no pós-operatório de exodontais de molares mandibulares

  • André Filipe Alves Martins (Student)

Student thesis: Master's Thesis

Abstract

Introduction: the search for an ideal antimicrobial agent has been studied in several health areas. Chlorhexidine has been widely used in the post-surgical period and is currently considered the gold standard. The search for new agents has highlighted hyaluronic acid in several areas of medicine, and good results have already been obtained in dentistry, particularly in the area of periodontology. Objective: comparative evaluation of the single intra-alveolar application of hyaluronic acid gel 0.2% vs. chlorhexidine gel 0.2%, in the postoperative period of mandibular molar extractions. Materials and methods: randomized, double-blinded, controlled clinical trial with current reference substance. The target population of this study comprised all the patients of the Oral Surgery Unit observed in the University Dental Clinic of Universidade Católica Portuguesa in Viseu. The sample was calculated using G.Power software (see 3.1.3): alpha value 0.05, statistical power 80%. The result was 74 (37 / group). The sample obtained to date included 33 patients so the results are considered preliminary. The patients were randomly assigned in 2 groups: 19 in group 1, with an intra-alveolar application of hyaluronic acid gel (0.2%) and 14 in group 2 with an intra-alveolar application of chlorhexidine gel (0.2 %), after the exodontia. The study comprised 2 clinical times: T0 – clinical data record and exodontia; T1 - postoperative evaluation of the variables: pain at 3 and 8 days, need for ibuprofen intake, occurrence of dry alveolitis, halitosis, haemorrhage, hematoma, trismus and extra-oral edema. Statistical analysis was performed in the SPSS software (v.24) through descriptive and inferential statistical tests (Mann-Whitney test and Fisher's exact test). Results: there was no statistically significant difference for all variables analyzed except for the occurrence of extra-oral edema. For this variable, there is statistical evidence (p=0.024) that the applied substance influences the occurrence of this complication. No adverse reactions were verified in relation to the substances used. Conclusions: within the limitations of this study, particularly the size of the sample, it was verified that hyaluronic acid presented more favorable results concerning extra-oral edema.
Date of Award12 Jul 2017
Original languagePortuguese
Awarding Institution
  • Universidade Católica Portuguesa
SupervisorAndré Correia (Supervisor)

Keywords

  • Hyaluronic acid
  • Tooth extraction
  • Chlorhexidine

Designation

  • Mestrado em Medicina Dentária

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