Avaliação dos tempos de relaxamento T1 miocárdico de voluntários saudáveis em ressonância magnética 3T

Abstract

Cardiac Magnetic Resonance Imaging (CMR) is an exam that allows the evaluation of the structure of the heart, seeing if the tissues are the way they should be. Some recent techniques that are part of a set of images acquired during a cardiac resonance, help to improve this last objective (Mapping Techniques, which allow quantify the changes in the characteristics of the cardiac muscle, through T1, T2 and T2* relaxation values). This study aims to determine T1 relaxation values in the cardiac muscle of healthy individuals, using GE's Discovery 3T scanner, allowing the use of the T1 mapping technique in patients in a sustained way. 31 healthy volunteers underwent T1 mapping in a 3T magnetic resonance equipment. MOLLI 5(3)3 sequence was used, acquiring a short-axis slice at mid-ventricular level. Native T1 values were presented as means (± standard deviation), and the independent samples t-test evaluated gender differences in T1 values. Results show an overall mean native T1 value of 1193 ± 39 ms, with women's values being statistically higher than men's (1211 ± 40 vs 1173 ± 27 ms, respectively, p < 0.006). Sex remained the sole determinant of native T1 times in a multiple linear regression model that included age, ejection fraction, and T2 status. This study established native T1 reference values for 3T GE Discovery scanner values, which are on par with those already reported by other vendors, for a similar sequence. We also found a correlation between native T1 and gender, with women presenting higher values than men. More studies are needed to confirm the influence of sex on native T1 values.

Date of Award	4 Dec 2023
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	António Silva Ferreira (Supervisor) & Tiago Emanuel Godinho Rodrigues Teixeira (Co-Supervisor)