Biomarcadores de cancro da cabeça e pescoço associados ao metabolismo de NAD

: uma revisão sistemática

Abstract

Introduction: Identifying biomarkers in Oncology might allow an increase in diagnostic accuracy, better patient selection and establishing prognosis for different types of cancer, namely head and neck cancer. Given its role in redox reactions, nicotinamide adenine dinucleotide (NAD) and NAD-related molecules might be involved in carcinogenesis, and their regulation could change as a response to tumor growth. Aim: Identifying NAD-related biomarkers in head and neck cancers. Methods: Controlled and natural terms were used in queries for searching scientific publications in databases, namely PubMed®, B-ON and Cochrane. Publications in English, regarding adult patients diagnosed with head and neck cancers, assessing NAD-related molecule expression were included. Experimental, analytical and exploratory cross-sectional studies were included.Results: 19 publications were included, and assessing biomarker expression in tumor samples (63.2%). Nicotinamide phosphoribosyltransferase (NAMPT, 42.1%) and sirtuin (31.6%) expression were the most used biomarkers, and the most used techniques were immunohistochemistry (42.1%) and polymerase chain reaction (31.6%). An increase in NAMPT expression was observed in head and neck cancers in all publications assessing this biomarker, with contradictory results regarding the expression of both sirtuins and CD38. Conclusions: The increase in NAMPT expression is consistent among head and neck tumors as a biomarker for this pathology.

Date of Award	2 Dec 2021
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Raquel Silva (Supervisor) & Patrícia Couto (Co-Supervisor)