Caracterização biológica dos materiais derivados do osso de choco para aplicação em endodontia

  • Maria Teresa Ribeiro Fortuna (Student)

Student thesis: Master's Thesis


Cuttlefish bone has two main components, the dorsal shield and the lamellar matrix, the latter being essentially made up of aragonite. Aragonite can be hydrothermally converted to calcium phosphates. Calcium phosphates are used as bone graft materials or added to dental materials, as they are chemically similar to the mineral phase of natural bone and tooth structure. The cuttle bone associated with bioglass favors biological responses and increases the resistance of this material. This work aims to evaluate the antimicrobial and cytotoxic properties of cuttle bone associated with bioglass, in order to select the intracanal medication material with the greatest potential for application in endodontics. Cell viability protocols and antimicrobial properties against C. albicans were developed and tested. It was noticeable an inhibition of the growth of C. albicans effective for the association of cuttlefish bone and bioglass. Both cuttle bone and bioglass show viability values above 70%. The application of this type of material is promising in the field of endodontics, and therefore, it is necessary to improve its antibacterial properties, with the option of incorporating ions and carrying out tests for Enterococcus faecalis.
Date of Award22 Jul 2021
Original languagePortuguese
Awarding Institution
  • Universidade Católica Portuguesa
SupervisorAna Sofia Duarte (Supervisor) & Rita Noites (Co-Supervisor)


  • Cuttlefish bone
  • Bioglasses
  • Endodontics
  • Intracanal medication
  • Cytotoxicity essays
  • Antimicrobial essays


  • Mestrado em Medicina Dentária

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