Caraterização da saúde oral e microbioma oral em pacientes com patologia gastrintestinal do Centro Hospitalar Tondela-Viseu

Abstract

Introduction: Oral health and microbiome are associated with inflammatory bowel disease (IBD). Thus, there is a need for an ostensive characterization of patients with this disease with a view to an adequate therapeutic approach.
The objectives of this study included: knowing the socio-demographic aspects, oral health behaviors and daily habits in patients with inflammatory bowel disease; characterize the oral health of patients with inflammatory bowel disease; analyze the oral microbiome of individuals who use the University Dental Clinic (CDU) and potential association with demographic and oral and systemic health characteristics and to relate oral microbiome profiles with the oral and systemic health status. Methods: The present observational cross-sectional study was based on 3 data collection strategies. Sociodemographic characteristics, oral health behaviors and daily habits as well as systemic health aspects were evaluated using two different questionnaires, respectively. An intraoral examination was also carried out with a view to the general dental and periodontal condition and, finally, biological material from saliva and biofilm was collected from the final sample of 14 patients diagnosed with IBD, 50% with Crohn’s Disease and 50% with Ulcerative Colitis, referred from the Gastroenterology service of Centro Hospitalar Tondela-Viseu for dental appointments at the CDU of the UCP. Results: The most represented level of schooling was Middle (35.71%), between the 9th and 12th grades; 57.14% of the participants have some form of periodontitis or gingivitis, where 21.42% have the most advanced stage of periodontitis. The DMFT index is 7.07 and half of the participants have a DMFT greater than 5. There was a lower total microbial load in patients with Ulcerative Colitis than with Crohn’s Disease. Conclusions:
This study allowed us to broaden our knowledge of factors such as health and the oral microbiome associated with IBD. The detailed characterization of patients associated with the quantification of the total microbial load in patients with this disease opens the door to future investigations with a view to adapting therapeutic protocols to each patient.

Date of Award	18 Jul 2022
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Nélio Jorge Veiga (Supervisor), Ana Peixoto Gomes (Co-Supervisor) & Paula Ministro (Co-Supervisor)