Comparison between tooth-derived matrix and DBBM granules on an enhanced bone healing
: a scoping review

  • Victor Cirfeda (Student)

Student thesis: Master's Thesis

Abstract

Purpose: The purpose of this project was to perform a scoping review on the comparison between tooth-derived matrix and demineralized bovine bone mineral (DBBM) granules for enhanced bone healing. Materials and Methods: A literature search was conducted on PubMed and Scopus electronic databases studies published in English until April 2024. The following keywords were assessed: "deproteinized bovine bone mineral" OR "DBBM" OR "Bio-Oss" AND "dentin matrix" OR "tooth-derived" OR "dentin" OR "dentin-derived" OR "ATDM" OR “ATDG” AND "bone substitute" OR “graft” OR “granule” OR “block” AND “bone” AND “healing” OR “repair” OR “augmentation” OR “regeneration” OR “growth” OR “formation” OR “osteoblast” OR “osteogenic” OR “mineralization” OR “cell culture”. Preliminary results: The dentin-matrix granules revealed micro-scale pores due to the remnant dentin that promote the adsorption of proteins and bioactive molecules. It should be highlighted the remnant dentin is intrinsic source of collagen and growth factors such as TGF-1, BMP-2, VEGF, and PDGF. The DBBM showed macro-scale interconnected pores which enhances the adhesion of cells and formation of new blood vessels. DBBM also revealed a porosity of around 80% and a lower resorption rate when compared to tooth-derived granules. On in vivo models, dentin-matrix granules induced quite similar results for bone growth when compared to grafting with DBBM as confirmed by histological analyses. Conclusions: The dentin-derived matrix granules showed morphological aspects and chemical composition suitable for enhancing bone repair comparable to the effects of deproteinized bovine bone mineral granules.The autologous dentin-derived graft is an effective alternative material for bone augmentation.
Date of Award30 Jul 2024
Original languageEnglish
Awarding Institution
  • Universidade Católica Portuguesa
SupervisorJúlio C. M. Souza (Supervisor) & Bruno Henriques (Co-Supervisor)

Keywords

  • Dentin-derived matrix
  • DBBM
  • Demineralized bovine bone mineral
  • Bone healing
  • Bone graft

Designation

  • Mestrado em Medicina Dentária

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