Objective: The current review’s purpose is to map the existing literature regarding the DMN so as to create a cohesive, comprehensive, and clear picture of the state of the art in order to arrive at better understanding of the network’s involvement and role in neurological pathologies, in the context of human consciousness, namely the disorders of consciousness. Introduction: Since its official discovery in 2001 by Raichle and colleagues 76 , the default-mode network, an extensive network of cortical regions that is mostly active in a resting-state of brain activity, has increasingly become the target for a plethora of studies in the mind and brain sciences. Methodology: The present scoping review adopted the Joanna Briggs Institute (see appendix IV) criteria for elaborating and developing scoping reviews. The search for articles for selection and metadata extraction began on the 7th of July, using the following data bases: CINAHL, PubMed, PsycArticles, Scopus, and Web of Science; all of the publications contemplated for the data bases listed above were considered for English, French, Portuguese, and Spanish. Inclusion Criteria: Inclusion criteria were decided upon using the PCC acronym, following JBI’s recommendation for scoping review protocols, where P corresponds to the population, C the concept, and C the context. The current project considered studies whose participant sample included patients with disorders of consciousness, as well as studies that touched upon the default-mode network, in the context of pathological human consciousness (DOC). Results: A final sum of thirty-three articles was reached and were included for the review. The results point to the DMN’s involvement in DOC pathologies with regards to playing a role in identifying the current state of the DOC, modulating it, and developing a prognostic for the evolution of the pathology. It may very well become a fundamental network to consider for future interventions in DOC rehabilitation. Discussion: The act of identifying the Default-mode network in disorders of consciousness may prove challenging depending on the aetiology of the lesion/injury, however, it has a profound impact in correctly categorising the current pathological state within this spectrum and is equally impactful in determining the probability of prognostic and pathological evolution. Also, through the use of guided cortical intra network (intra-DMN) interventions via electrophysiological stimulation, or through the administration of drugs that target this network, it is becoming clearer that there is an increasing body of evidence that implicates the DMN in playing a key role in DOC.
- Default-mode network
- Disorders of consciousness
- Mestrado em Neuropsicologia
Default-mode network e as doenças de consciência: uma revisão scoping
Miles, C. A. C. (Student). 15 Dec 2023
Student thesis: Master's Thesis