Glico-OralOma na perimplantite

Abstract

Despite the increased emphasis on preventive dentistry in recent years, remains high the number of partial or total edentulous people, requiring treatments that restore functionality. Therefore, implantology has become the main area of specialisation for these problems to be minimized, recovering quality of life. Peri-implantitis, the late failure of the dental implant, is an inflammatory process affecting the tissues surrounding an osseointegrated implant in function, resulting in the loss of supporting bone. This pathology has consequences both economically and in the oral health of patients. Thus, it is urgent to identify the molecular mechanisms that are involved on it. The aim of this work is to identify altered proteins and glycoproteins whose activity can be modified, in order to identify not only the molecular processes that are engaged in peri-implantitis, but also to clarify the contribution of flora that is present in different ways in this pathology. Using the computational biomedicine, it was possible to process data in order to equate molecular reasons underlying peri-implantitis. Establishing periimplantitis proteome allowed to add 39 proteins to OralCard database, making possible for the first time to compile periimplantitis information in this database. Functional characterization of the peri-implantitis OralOma led to identify changes in certain molecular functions, biological processes and signaling pathways. It was not possible to determine the Glyco-OralOme due to lack of information. Regarding the periimplantitis microbiome it was noted the lack of studies in this area, being only identified five genders as increased in peri-implantitis. Similarly, there was a paucity of data that would allow establishing relationships with peri-implantitis when of the interactomics examination. This work helped to clarify the molecular mechanisms that lead to bone loss around the implant, which may allow the establishment of targets for further experimental studies and new approaches in clinical intervention in peri-implantitis.

Date of Award	2013
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Marlene Barros (Supervisor) & Bruno José Manadas (Co-Supervisor)