Inflamação e eritropoiese

: efeito da perda de peso associado à cirurgia de banda gástrica

Abstract

Accumulating evidence indicates that a state of chronic inflammation has a crucial role in the pathogenesis of obesity-related metabolic dysfunction. This study aims to evaluate changes in inflammatory process, iron metabolism, erythropoiesis and lipid profile associated with weight loss after gastric banding surgery. Forty six patients were evaluated before and 3 months after gastric banding surgery. A survey was conducted with recording of demographics, body mass index (BMI) and records the presence of co morbidities. Moreover, complete blood cell counts and serum levels of iron, ferritin, transferrin, high sensitivity C-reactive protein (hsCRP), total cholesterol, LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c) and triglycerides (TG) were performed. Three months after surgery our patients presented a significant decreased in weight and BMI, associated with a decreased in inflammatory process (decreased hsPCR, ferritin, neutrophil counts and neutrophil/lymphocyte ratio), increased iron availability (increase in transferrin saturation and a trend to higher iron serum levels), decreased erythropoisis (decreased in reticulocytes counts and reticulocyte production index) and significant decreased in TG and in Tg/HDL-cholesterol ratio. Our results showed a significant decrease in the inflammation process, 3 months after gastric banding surgery, which might be associated with adipose tissue loss. This decreased in the inflammatory process results in more efficient iron absorption and increasing iron availability for erythropoiesis. Moreover, we also found a decreased TG serum levels. These changes suggest benefits from gastric band surgery, including decreased risk of cardiovascular disease

Date of Award	12 Jan 2014
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Elísio Costa (Supervisor) & Luís Monteiro (Supervisor)