O oraloma da diabetes melitus tipo 1 vs diabetes melitus tipo 2

: um estudo comparativo

Abstract

Diabetes Mellitos is a disease with high prevalence worldwide with pathophysiological mechanisms not yet fully understood. Nowadays, the therapeutical approach of Diabetes Mellitos is mainly a symptomatic one based on insulin administration to type 1 Diabetes Mellitus patients and type 2 Diabetes Mellitus patients with no funtional pancreatic beta-cells or the serum glucose concentration control in type 2 Diabetes Mellitus patients. Hyperglykemia is a carachteristic phenotype of this pathology, it brings long-run negative effects on the organism due to its role on modifying proteins structure and function affecting the organism's integrity. Both Diabetes Mellitus types influence, on different ways, protein expression hence leading to changes on the molecular signaling pathways and biologic process of the cells. Thereafter, to know the molecular aspects of both Diabetes Mellitus types is key to develop better, more efficient and precocious diagnostic and therapeutic tecniques. Based on the oral proteome, namely the oralome, this study aims to update data from the pre-existing oral proteomic studies on both types of Diabetes Mellitus and to study them using bioinformatic tools which allow these proteins carachterization. Being an ecossystem, the oral cavity is inseparable of the microrganisms which inhabit in it. Therefore, another aim of the present study is to annotate the microrganisms species identified by the current scientific literature, in order to charactherize in a more complete way this molecular aspect of the oral cavity.

Date of Award	2013
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Nuno Rosa (Supervisor)