Introduction. Head and neck squamous cell carcinoma is the histological subtype of head and neck cancer with the highest incidence (about 90% of cases). The main forms of treatment are surgery, radiotherapy and interventions such as chemotherapy, targeted molecular therapy and immunotherapy. This work aimed to synthesize the existing knowledge in the literature about the possible impact of SNPs (single nucleotide polymorphisms) involved in DNA repair pathways on the outcome of treatment (radiotherapy, chemotherapy or both) in patients diagnosed with squamous cell carcinoma of the head and neck. Methods. A systematic review was performed using the PICO strategy (Population, Intervention, Comparison and Outcome) and complying with the PRISMA criteria. The search expression was entered into the WoS (Web of Science) and PubMed databases. Initially, filters and/or restrictions were not used for the searches. With the help of the Rayyan platform, two independent reviewers selected 37 articles from the search results for inclusion in our study. Results. The outcomes analyzed were grouped into therapy toxicity (n=45), global outcome for the patient (n=41) and therapy efficacy (n=17). The most studied anatomical sites were the hypopharynx and the oropharynx. The most common DNA repair pathway was NER. The most frequent gene in the studies was ERCC2. The most commonly used medication was cisplatin. Conclusion. The SNPs present in DNA repair genes are excellent biological markers for studying the response to chemotherapy and/or radiotherapy. However, the complexity of the biological processes of DNA repair pathways, the presence of factors such as ethnicity, stage and anatomical location of tumors, alcohol consumption, smoking and previous HPV infections make it difficult to standardize research in order to achieve results with greater reliability.
Date of Award | 16 Oct 2024 |
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Original language | Portuguese |
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Awarding Institution | - Universidade Católica Portuguesa
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Supervisor | Luís Santos (Supervisor) & Maria José Correia (Co-Supervisor) |
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- Single nucleotide polymorphism
- DNA repair
- Squamous cell carcinoma of head and neck
- Antineoplastic agents
- Radiotherapy
- Chemoradiotherapy
- Mestrado em Medicina Dentária
O potencial impacto de SNPs em vias de reparação genética no tratamento do carcinoma de células escamosas da cabeça e pescoço: revisão sistemática
Naili, K. L. (Student). 16 Oct 2024
Student thesis: Master's Thesis