The oral cavity presents a wide range of human and microbial proteins. This study aims to identify and annotate the human and microbial proteins in the literature associated with endodontic infection. The study developed identified 523 proteins being 385 microbial and 138 human, of which 96 are unique proteins of endodontic pathology. The information on these proteins has been noted in the database OralOme which can be accessed via the web by OralCard interface. Functional characterization of the endodontic OralOma disease possible to infer an increased number of molecular processes involved in protein activity and receptor transport activity. The determination of protein-protein interactions between human proteins and microbial proteins identified that a large number of interactions are associated with defense functions and attempt invasion of host tissues. Many proteins identified in the endodontic disease don’t present quantification data and merely identifying potential biomarkers for endodontic disease. This suggest new studies of proteomics to enable this quantification.
Date of Award | 9 Dec 2016 |
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Original language | Portuguese |
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Awarding Institution | - Universidade Católica Portuguesa
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Supervisor | Marlene Barros (Supervisor) & Rita Noites (Co-Supervisor) |
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- Endodontic infections
- Salivar diagnosis
- Proteomics
- Oral microbiome
- Mestrado em Medicina Dentária
O proteoma nas infeções endodônticas
Monteiro, L. M. M. (Student). 9 Dec 2016
Student thesis: Master's Thesis