Oral complications of cancer treatment in patients with breast neoplasm
: a retrospective observational study in a hospital setting

  • José Francisco da Silva Gonçalves (Student)

Student thesis: Master's Thesis


The overall incidence of cancer, particularly breast cancer, has increased substantially over the last decades, with the oral cavity being one of the locations where side effects usually occur, namely osteochemonecrosis, as a consequence of the use of drugs such as bisphosphonates and, more recently, monoclonal antibodies. Purpose: To analyse and further characterise the main oral manifestations of cancer treatment associated with patients with breast neoplasm. Material and methods: A retrospective observational study as carried out. Records from 32 patients undergoing chemotherapy will be retrieved from the Hospital Santos Silva (CHVNG/E) files and reviewed. Patients will subsequently be observed and a questionnaire applied. Tumour type, stage, therapeutic regimens, and oral manifestations will be determined and a statistical analysis performed using SPSS 21.0. Results: A sample of 32 patients was obtained. Invasive Carcinoma were the most common breast neoplasm form with an incidence of 56.25% (n=18). Stage IIA was the most common with an incidence of 25 % (n=8). FEC, 46.9% (n=15), was the most employed therapeutic chemotherapy regimens. Dysgeusia was the most common oral complication observed with an incidence of 81.3% (n=26) Conclusion: The awareness for oral complications during breast neoplasm between patients is very low and undervalued by them. More study on the subject are necessary so that the quality of life for the oncological patient can be improved significantly.
Date of Award2 Nov 2015
Original languageEnglish
Awarding Institution
  • Universidade Católica Portuguesa
SupervisorRui Alberto Amaral Mendes (Supervisor)


  • Complications
  • Oral
  • Breast neoplasm
  • Cancer therapy
  • Chemotherapy
  • Radiotherapy
  • Mucositis


  • Mestrado em Medicina Dentária

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