Oraloma da peri-implante

Abstract

Rehabilitation of edentulous areas can be performed using implants-supported denture prostheses. These provide the patient with a clinical situation more similar to the natural dentition, improving their quality of life. The evolution of implantology, associated with socioeconomic reasons, has led to an increase in the number of implants placed in the last three decades. This fact, associated to the longer in vivo maintenance, has favoured the incidence of peri-implantitis. This is defined as an inflammation of the peri-implant tissues with loss of supporting bone, ultimately resulting in failure of the prosthetic solution. Accordingly, the present dissertation proposed to update the molecular information in peri-implantitis, through the identification and clarification of the molecular mechanisms with impact in the establishment and progression of the disease. This investigation allowed to add 58 new proteins to the OralOma of peri-implantitis, joining the 38 previously catalogued. Functional analysis showed an increase in the interference of certain proteins. In particular, over-regulation of IL1 and MPO and down-regulation of IL10 were indicated as inflammatory markers; an increase in MMP8 seems to suggest the process of connective tissue destruction; and over-regulation of RANK, RANKL and TNF- , as well as the down-regulation of OPG, are promising biomarkers of bone remodelling. However, for the possible application of these in the future, it is necessary to establish a standard protocol for the collection and analysis of PICF and saliva, in order to characterize the pattern values for each substance, as it currently exists for blood. It is hoped that the data generated in this work may contribute to the identification of proteins and molecular mechanisms that allow the early diagnosis, determination of the patient’s susceptibility and determination of the prognosis of the affected implants. This knowledge can help guide personalized treatment approaches and evaluate the success of therapy.

Date of Award	18 Jul 2017
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Nuno Rosa (Supervisor), Marlene Barros (Co-Supervisor) & André Correia (Supervisor)