Proporção dos diferentes tipos de Vírus do Papiloma Humano no colo do útero de mulheres infectadas pelo Vírus da Imunodeficiência Humana

Abstract

Cervical carcinoma is the second most frequent neoplasia in women and is an AIDS (Acquired Immunodeficiency Syndrome) defining disease. HIV (Human Immunodeficiency Virus) infected women are more susceptible to persistent HPV infection, infection by multiple HPV, and have more frequent intraepithelial lesions and cervical carcinomas. The prevalence of the different types of HPV is not well known in the HIV infected population in Portugal. We analyzed 103 cervical cytologies of 87 women infected with HIV 1 and HIV 2 for cytological abnormalities and HPV genotyping. We observed that 31% of the women were infected with only one HPV and that in 33.3% of the women no HPV was detected. The remaining 35.7% were infected with more than one virus. HPV 16 was the most frequently detected HPV (12.6% of the cases) followed by HPV 62 and 58 (10.3% of the cases each), HPV 51 and 42 (9.2% of the cases each) and HPV 61 (8% of the cases). In the caucasian population the HPV more frequently detected were HPV 16, 62, 61 and 66. In the African population the more frequently detected HPV were HPV 35, 42, 58, and 70. HPV were detected in greater numbers per woman in the African population when compared to the caucasian. The average viral load of the patients was 13,077.65 copies/mL and the average CD4 count was 509.35 cells/μL. No statistically significant associations were found between viral load and HPV. For CD4 counts bellow 200 cells/μL a weak but statistically significant association with HPV 42, 43, 44, and 82 was found. In 45 (58.4%) of the 77 women with a normal cervical cytology there was at least one HPV detected. Our results may contribute to the planning of future HPV screening and vaccination strategies in women infected with HIV.

Date of Award	2011
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Maria Teresa d’Avillez Paixão (Supervisor) & Ângela Maria Chambel Pista (Co-Supervisor)