Aim: The aim of this umbrella review is to determine the risk factors associated with cancer-related oral mucositis in children and to establish a system for evidence-based grading of each individual factor. Materials and Methods: This umbrella review was registered with PROSPERO (CRD42023477370). The study was conducted in accordance with the PRISMA guidelines. Four databases were used. The literature search was carried out on 26 November 2023. The inclusion criteria were systematic reviews read in full in English, in a paediatric population with oral mucositis and exposed to oncological treatment. The exclusion criteria were oral mucositis not derived from oncological treatment, systematic reviews that did not include risk factors and letters to the editor, critical reviews and primary research studies. 101 articles were retrieved, excluding duplicates (n=4). The title and abstract of these 97 articles were read, of which 86 were excluded because they did not mention oral mucositis and children. 11 articles were read in full and 6 were excluded because they did not mention risk factors. Results: 5 articles were evaluated in this study. The most relevant risk factors for the development of oral mucositis were the type of tumour and the chemotherapeutic agent. Low body weight, haematological, hepatic, renal parameters and poor oral hygiene were also relevant factors. High levels of creatine, ALT and AST, multivitamins and high levels of total and indirect bilirubin were factors mentioned, although in a less significant number of articles. Conclusion: The type of tumour and the chemotherapy modality are risk factors for OM, however, further studies are required in this field to establish robust evidence and guide the management of oral mucositis.
- Oral mucositis
- Children
- Cancer treatment
- Risk factors
- Cancer
- Mestrado em Medicina Dentária
Risk factors for cancer treatment-related oral mucositis in children: an umbrella review
Henrique, T. D. S. (Student). 16 Jul 2024
Student thesis: Master's Thesis