Síndrome de Sjögren perfil epidemiológico potencial valor de diagnóstico salivar

: case report

Abstract

BACKGROUND: Sjögren's syndrome is an autoimmune systemic rheumatic disease characterized by lymphocytic inflammation of the exocrine glands, resulting in its hypofunction. Two types of Sjögren's syndrome can be distinguished: primary and secondary, the first reaches the exocrine glands, the second is associated with other autoimmune diseases, making diagnosis a challenge, validating the argument of considering the diagnosis as a complementary means of salivary diagnostics. OBJECTIVES: To describe the epidemiology of Sjögren's syndrome and emphasize the importance of diagnosis by salivary proteomics. MATERIALS AND METHODS: Compilation of the salivary proteome of Sjögren's syndrome by consulting OralCard using the term "Sjogren's Syndrome". Bibliographic research on B-on , Pubmed , Medline and Science direct  using the keywords, "Sjogren's Syndrome", "saliva", "raw *", "diagnostics" The characterization and functional interpretation was performed using the PANTHER bioinformatics tools and STRING. Presentation of case report aims to highlight the applicability and usefulness of salivary early diagnosis, as an alternative to invasive tests and costly diagnoses. RESULTS: 477 salivary proteins involved in Sjögren's syndrome were found in OralCard, of which 33 are involved in the immune response. By identifying these 33 proteins biological functions were obtained, of which five are increased in the immune response. In evaluating the clinical case, when basal salivary flow was analyzed, it was less than half the amount considered normal, which is about 0.30 ml / minute. The intra and extra-oral examination was carried out in detail and results were evaluated, which are consistent with the literature search. CONCLUSIONS: This study compiles and briefly characterizes the salivary proteome of Sjögren's syndrome. It is suggested the design of laboratory strategies to enable the quantification of these same proteins. It is imperative to include another additional diagnostic procedures, less invasive and carry out on an early stage of the disease, based on the identification of salivary biomarkers.

Date of Award	2014
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Cláudia Ribeiro (Supervisor) & Nuno Rosa (Co-Supervisor)