Testes de diagnóstico em saliva para apoio à medicina dentária de precisão

: scoping review

Abstract

Introduction: Over the years, saliva has gained great importance for diagnostic purposes for oral and systematic diseases. As a result, several diagnostics tests were developed with the aim of having a clinical application, such as “chair side” and “point of care”. These results allow the patient to have a personalized treatment for their condition with the nest clinical approach and minimal undesirable effects. However, few have been applied in a clinical context due to numerous facts, which makes it impossible to use it to support clinical decision and treatment. Objectives: Identify the saliva diagnostic tests developed until now that are validated and/or commercialized and verify those that have the biggest potencial for application in the context of dentistry. Due to these results, we propose new tests for the pratice of Precision Dentistry. Materials and Methods: A search strategy was done in Pubmed, Scopus and Web of Science to evaluate the applicability of saliva diagnostic tests in dentistry through a Scoping Review. The “PRISMA Extension for Scoping Reviews (PRISMA-ScR)” strategy was followed to select and analize the articles to be considered in this ScR. Results: Twelve validated and/or commercialized saliva diagnostic tests were found for periodontitis, decays, AIDS, HPV, stress, oral cancer and halitosis. These tests allow monitoring and early diagnosis of these diseases. Conclusion:
Despite there being a great variability of saliva diagnostic tests, few were validated and commercialized. One of the main weaknesses of most of the identified tests is that they evaluate only one biomarker, compromising the specificity and efficacy for diagnosing certain diseases. Further studies with multiple biomarkers should be performed in order to make a more accurate and effective diagnosis.

Date of Award	24 Jul 2024
Original language	Portuguese
Awarding Institution	Universidade Católica Portuguesa
Supervisor	Nuno Rosa (Supervisor) & Rita Bornes (Co-Supervisor)