Transcranial Alternating Current Stimulation for the improvement of episodic memory in healthy older adults

This study is a randomized, double-blind, sham-controlled, crossover clinical trial that will include 16 healthy adults aged 65 or over without cognitive deficits. Participants will be randomized into two groups in a 1:1 ratio, and the order of administration of either intervention (i.e., γ-tACS or sham) will be counterbalanced across all patients. tACS will be applied daily for five days in the precuneus at a frequency of 40 Hz for 60 minutes. The pre- and post-stimulation effects of tACS will be evaluated. The primary outcome measures will be the Auditory Verbal Learning Test (AVLT) and Face-Name Memory Test (FNMT), and the secondary outcome measure will be the changes in functional connectivity between the precuneus and hippocampus assessed by resting-state electroencephalography (rs-EEG).