Accumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Hér and their antioxidant and anti-cholinesterase potential

Patrícia Costa, Sandra Gonçalves, Patrícia Valentão, Paula B. Andrade, Anabela Romano*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

51 Citações (Scopus)

Resumo

In this study, we evaluated the phenolic profile, antioxidant and anti-cholinesterase potential of different extracts from wild plants and in vitro cultures of Lavandula viridis L'Hér. The HPLC-DAD analysis allowed the identification and quantification of 3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids, and luteolin and pinocembrin. Water/ethanol extract from in vitro cultures contained the highest amount of the identified phenolic compounds (51652.92mg/kg). To investigate the antioxidant activity we used Trolox equivalent antioxidant capacity, oxygen radical absorbance capacity, Fe2+ chelation activity and the inhibition of Fe2+-induced lipid peroxidation in mouse brain homogenates (in vitro). Overall, all the extracts from both wild plants and in vitro cultures exhibited ability to scavenge free radicals, to chelate Fe2+ and to protect against lipid peroxidation. In addition, the extracts from L. viridis were active in inhibiting both acetylcholinesterase and butyrylcholinesterase (Ellman's method). Our findings suggest that L. viridis in vitro cultures represent a promising alternative for the production of active metabolites with antioxidant and anti-cholinesterase activity.

Idioma originalEnglish
Páginas (de-até)69-74
Número de páginas6
RevistaFood and Chemical Toxicology
Volume57
DOIs
Estado da publicaçãoPublicado - jul. 2013
Publicado externamenteSim

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