Anti-TNF withdrawal in inflammatory bowel disease

Joana Torres; Marília Cravo; Jean Frédéric Colombel

doi:10.1016/j.jpge.2015.11.004

Anti-TNF withdrawal in inflammatory bowel disease

Título traduzido da contribuição: Discontinuação dos Anti-TNF na doença inflamatória intestinal

Joana Torres^*
, Marília Cravo
, Jean Frédéric Colombel

^*Autor correspondente para este trabalho

Resultado de pesquisa › revisão de pares

10 Citações (Scopus)

Resumo

A introdução dos anti-TNFα na prática clínica produziu um avanço considerável no tratamento da doença inflamatória intestinal. A utilização destes medicamentos resulta numa remissão duradoura num sub-grupo de doentes, evitando cirurgias e hospitalização. No entanto, existem algumas preocupações com a segurança e o custo associados com a sua utilização a longo prazo. Assim, a descontinuação dos anti-TNFα tem emergido como uma questão importante na prática clínica. Pretendemos neste artigo, discutir a evidência disponível sobre interrupção dos anti-TNFα na doença inflamatória intestinal, proporcionando ao clínico informação actualizada sobre as taxas de recidiva após interrupção do fármaco, potenciais factores predictores de recidiva, assim como a resposta ao re-tratamento.

Título traduzido da contribuição	Discontinuação dos Anti-TNF na doença inflamatória intestinal
Idioma original	English
Páginas (de-até)	153-161
Número de páginas	9
Revista	GE Portuguese Journal of Gastroenterology
Volume	23
Número de emissão	3
DOIs	https://doi.org/10.1016/j.jpge.2015.11.004
Estado da publicação	Publicado - 1 mai. 2016
Publicado externamente	Sim

ODS da ONU

Este resultado contribui para o(s) seguinte(s) Objetivo(s) de Desenvolvimento Sustentável

ODS 3 Boa saúde e bem-estar

Keywords

Doença Inflamatória Intestinal/tratamento
Inibidores Factor de Necrose Tumoral Alfa/antagonistas & inibidores
Factor de Necrose Tumoral Alfa/uso terapêutico
Suspensão de tratamento

Acesso ao documento

10.1016/j.jpge.2015.11.004Licença:

Outros arquivos e links

Link to publication in Scopus

Citação

@article{2c9acc2a9baf49a2b6fa7f462c127b58,

title = "Anti-TNF withdrawal in inflammatory bowel disease",

abstract = "The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF withdrawal has emerged as an important consideration in clinical practice. Herein our goal was to discuss the available evidence about anti-TNFα discontinuation in IBD that could inform the clinician on the expected rates of relapse, the potential predictors of relapse, as well the response to re-treatment.",

keywords = "Inflammatory Bowel Diseases/drug therapy, Tumor Necrosis Factor-Alpha/antagonists and inhibitors, Tumor Necrosis Factor-Alpha/therapeutic use, Withholding treatment, Doen{\c c}a Inflamat{\'o}ria Intestinal/tratamento, Inibidores Factor de Necrose Tumoral Alfa/antagonistas \& inibidores, Factor de Necrose Tumoral Alfa/uso terap{\^e}utico, Suspens{\~a}o de tratamento",

author = "Joana Torres and Mar{\'i}lia Cravo and Colombel, \{Jean Fr{\'e}d{\'e}ric\}",

note = "Publisher Copyright: {\textcopyright} 2015 Sociedade Portuguesa de Gastrenterologia.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.jpge.2015.11.004",

language = "English",

volume = "23",

pages = "153--161",

journal = "GE Portuguese Journal of Gastroenterology",

issn = "2341-4545",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Anti-TNF withdrawal in inflammatory bowel disease

AU - Torres, Joana

AU - Cravo, Marília

AU - Colombel, Jean Frédéric

PY - 2016/5/1

Y1 - 2016/5/1

N2 - The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF withdrawal has emerged as an important consideration in clinical practice. Herein our goal was to discuss the available evidence about anti-TNFα discontinuation in IBD that could inform the clinician on the expected rates of relapse, the potential predictors of relapse, as well the response to re-treatment.

AB - The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF withdrawal has emerged as an important consideration in clinical practice. Herein our goal was to discuss the available evidence about anti-TNFα discontinuation in IBD that could inform the clinician on the expected rates of relapse, the potential predictors of relapse, as well the response to re-treatment.

KW - Inflammatory Bowel Diseases/drug therapy

KW - Tumor Necrosis Factor-Alpha/antagonists and inhibitors

KW - Tumor Necrosis Factor-Alpha/therapeutic use

KW - Withholding treatment

KW - Doença Inflamatória Intestinal/tratamento

KW - Inibidores Factor de Necrose Tumoral Alfa/antagonistas & inibidores

KW - Factor de Necrose Tumoral Alfa/uso terapêutico

KW - Suspensão de tratamento

UR - https://www.scopus.com/pages/publications/85006197292

U2 - 10.1016/j.jpge.2015.11.004

DO - 10.1016/j.jpge.2015.11.004

M3 - Short survey

C2 - 28868451

AN - SCOPUS:85006197292

SN - 2341-4545

VL - 23

SP - 153

EP - 161

JO - GE Portuguese Journal of Gastroenterology

JF - GE Portuguese Journal of Gastroenterology

IS - 3

ER -

Anti-TNF withdrawal in inflammatory bowel disease

Resumo

ODS da ONU

Keywords

Acesso ao documento

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