Antibacterial and healing effect of chicha gum hydrogel (sterculia striata) with nerolidol

Idglan Sá de Lima, Maria Onaira Gonçalves Ferreira, Esmeralda Maria Lustosa Barros, Marcia dos Santos Rizzo, Jailson de Araújo Santos, Alessandra Braga Ribeiro, Josy Anteveli Osajima Furtini, Edson C. Silva-Filho, Leticia M. Estevinho*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

4 Citações (Scopus)
15 Transferências (Pure)

Resumo

Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL−1. Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100–3550 cm−1. The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL−1 nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.

Idioma originalEnglish
Número do artigo2210
Número de páginas20
RevistaInternational Journal of Molecular Sciences
Volume24
Número de emissão3
DOIs
Estado da publicaçãoPublicado - 22 jan. 2023

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