Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis

Dustin G. Shaw, Raúl Aguirre-Gamboa, Marcos C. Vieira, Saideep Gona, Nicholas DiNardi, Anni Wang, Anne Dumaine, Jody Gelderloos-Arends, Zachary M. Earley, Katherine R. Meckel, Cezary Ciszewski, Anabella Castillo, Kelly Monroe, Joana Torres, Shailja C. Shah, Jean Frédéric Colombel, Steven Itzkowitz, Rodney Newberry, Russell D. Cohen, David T. RubinChristopher Quince, Sarah Cobey, Iris H. Jonkers, Christopher R. Weber, Joel Pekow, Patrick C. Wilson, Luis B. Barreiro*, Bana Jabri*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

2 Citações (Scopus)

Resumo

Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combining flow cytometry, bulk and single-cell transcriptomics, and T and B cell receptor repertoire analysis of right colon tissue from 65 patients with PSC, 108 patients with IBD and 48 healthy individuals we identified a unique adaptive inflammatory transcriptional signature associated with greater risk and shorter time to dysplasia in patients with PSC. This inflammatory signature is characterized by antigen-driven interleukin-17A (IL-17A)+ forkhead box P3 (FOXP3)+ CD4 T cells that express a pathogenic IL-17 signature, as well as an expansion of IgG-secreting plasma cells. These results suggest that the mechanisms that drive the emergence of dysplasia in PSC and IBD are distinct and provide molecular insights that could guide prevention of colorectal cancer in individuals with PSC.

Idioma originalEnglish
Páginas (de-até)1520-1529
Número de páginas10
RevistaNature Medicine
Volume29
Número de emissão6
DOIs
Estado da publicaçãoPublicado - jun. 2023
Publicado externamenteSim

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