TY - JOUR
T1 - Bioactivity and bioaccessibility of bioactive compounds in gastrointestinal digestion of tomato bagasse extracts
AU - Coelho, Marta
AU - Oliveira, Carla
AU - Coscueta, Ezequiel R.
AU - Fernandes, João
AU - Pereira, Ricardo N.
AU - Teixeira, José A.
AU - Rodrigues, António Sebastião
AU - Pintado, Manuela E.
N1 - Funding Information:
This research was funded by “MultiBiorefinery.: Estratégias multiuso para a valorização de uma gama alargada de subprodutos agroflorestais e das pescas: Um passo em frente na criação de uma biorrefinaria” financiado pelo Programa Operacional Competitividade e Internacionalização (POCI-01-0145-FEDER-016403) e pelo Programa Operacional Regional de Lisboa(LISBOA-01-0145-FEDER-016403), na sua componente FEDER e pela Fundação para a Ciência e Tecnologia, I.P. na componente nacional (SAICTPAC/0040/2015).
Funding Information:
Acknowledgments: The authors would like to thank the CCTI group that kindly provided the samples. Also to thank to project Co-promoção nº 016403, “MULTIBIOREFINERY”, supported by Programa Operacional Competitividade e Internacionalização and by Programa Operacional Regional de Lisboa, in its component FEDER, and by Fundação para a Ciência e Tecnologia, byprojects UID/Multi/50016/2020 and UIDB/04469/2020 administrated by FCT, and by the I&D&I AgriFood XXI project (NORTE-01-0145-FEDER-000004) co-funded by the European Regional Development Fund under the scope of Norte2020 (Programa Operacional Regional do Norte 2014/2020) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020-Programa Operacional Regional do Norte. Furthermore, the author Marta Coelho would like to acknowledge FCT for your PhD grant with the reference [grant number SFRH/BD/111884/2015].
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/6
Y1 - 2022/4/6
N2 - A nutrient-rich diet is a key to improving the chemical signals, such as antioxidants, which modulate pathogens’ resistance in the gut and prevent diseases. A current industrial problem is the generation of undervalued by-products, such as tomato bagasse, which are rich in bioactive compounds and of commercial interest (carotenoids and phenolic compounds). This work analyzed the effect of gastrointestinal digestion on the bioactivity and bioaccessibility of carotenoids and phenolic compounds from tomato bagasse extracts. Thus, the extraction by ohmic heating (OH) technology was compared with conventional (organic solvents). The results showed that the main phenolic compounds identified by UPLC-qTOF-MS were p-coumaric acid, naringenin, and luteolin. A higher recovery index for total phenolic compounds throughout the gastrointestinal digestion was observed for OH while for carotenoids, a strong reduction after stomach conditions was observed for both extracts. Furthermore, colon-available fraction exhibited a prebiotic effect upon different Bifidobacterium and Lactobacillus, but a strain-dependent and more accentuated effect on OH. Thus, the extraction technology highly influenced bioaccessibility, with OH demonstrating a positive impact on the recovery of bioactive compounds and related health benefits, such as antioxidant, anti-hypertensive, prebiotic, and anti-inflammatory properties. Of these properties, the last is demonstrated here for the first time.
AB - A nutrient-rich diet is a key to improving the chemical signals, such as antioxidants, which modulate pathogens’ resistance in the gut and prevent diseases. A current industrial problem is the generation of undervalued by-products, such as tomato bagasse, which are rich in bioactive compounds and of commercial interest (carotenoids and phenolic compounds). This work analyzed the effect of gastrointestinal digestion on the bioactivity and bioaccessibility of carotenoids and phenolic compounds from tomato bagasse extracts. Thus, the extraction by ohmic heating (OH) technology was compared with conventional (organic solvents). The results showed that the main phenolic compounds identified by UPLC-qTOF-MS were p-coumaric acid, naringenin, and luteolin. A higher recovery index for total phenolic compounds throughout the gastrointestinal digestion was observed for OH while for carotenoids, a strong reduction after stomach conditions was observed for both extracts. Furthermore, colon-available fraction exhibited a prebiotic effect upon different Bifidobacterium and Lactobacillus, but a strain-dependent and more accentuated effect on OH. Thus, the extraction technology highly influenced bioaccessibility, with OH demonstrating a positive impact on the recovery of bioactive compounds and related health benefits, such as antioxidant, anti-hypertensive, prebiotic, and anti-inflammatory properties. Of these properties, the last is demonstrated here for the first time.
KW - Lycopersicon esculentum
KW - Bioaccessibility
KW - Bioactivity
KW - Carotenoids
KW - Ohmic heating
KW - Phenolic compounds
UR - http://www.scopus.com/inward/record.url?scp=85128621113&partnerID=8YFLogxK
U2 - 10.3390/foods11071064
DO - 10.3390/foods11071064
M3 - Article
C2 - 35407151
SN - 2304-8158
VL - 11
JO - Foods
JF - Foods
IS - 7
M1 - 1064
ER -