Can corrole dimers be good photosensitizers to kill bacteria?

Paula S. S. Lacerda, Maria Bartolomeu, Ana T. P. C. Gomes, Ana S. Duarte, Adelaide Almeida, Maria A. F. Faustino, Maria G. P. M. S. Neves, Joana F. B. Barata*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

Resumo

Corroles possess key photophysical and photochemical properties to be exploited as thera-peutic agents in antimicrobial photodynamic therapy (aPDT). Herein, we present for the first time the antimicrobial efficiency of three corrole dimers and of the corresponding precursor against the Gram(+) bacterium Staphylococcus aureus. Additionally, to explore future clinical applications, the cytotoxicity of the most promising derivatives towards Vero cells was evaluated. The aPDT assays performed under white light irradiation (50 mW/cm2; light dose 450 J/cm2) and at a corrole concen-tration of 15 µM showed that some dimers were able to reduce 99.9999% of S. aureus strain (decrease of 5 log10 CFU/mL) and their photodynamic efficiency was dependent on position, type of linkage, and aggregation behavior. Under the same light conditions, the corrole precursor 1 demonstrated notable photodynamic efficiency, achieving total photoinactivation (>8.0 log10 CFU/mL reduction) after the same period of irradiation (light dose 450 J/cm2). No cytotoxicity was observed when Vero cells were exposed to corrole 1 and dimer 3 for 24 h according to ISO guidelines (ISO 10993-5) for in vitro cytotoxicity of medical devices. The results show that corrole dimers, dependent on their structures, can be considered good photosensitizers to kill Staphylococcus aureus.

Idioma originalEnglish
Número do artigo1167
Número de páginas14
RevistaMicroorganisms
Volume10
Número de emissão6
DOIs
Estado da publicaçãoPublished - 7 jun 2022

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