Projetos por ano
Resumo
Carboxymethyl cellulose is the most used water-soluble cellulose with applications in industries such as food, cosmetics, and tissue engineering. However, due to a perceived lack of biological activity, carboxymethyl cellulose is mostly used as a structural element. As such, this work sought to investigate whether CMC possesses relevant biological properties that could grant it added value as a cosmeceutical ingredient in future skincare formulations. To that end, CMC samples (Mw between 471 and 322 kDa) skin cell cytotoxicity, impact upon pro-collagen I α I production, and inflammatory response were evaluated. Results showed that samples were not cytotoxic towards HaCat and HDFa up to 10 mg/mL while simultaneously promoting intracellular production of pro-collagen I α I up by 228% relative to the basal metabolism, which appeared to be related to the highest DS and Mw. Additionally, CMC samples modulated HaCat immune response as they decreased by ca. 1.4-fold IL-8 production and increased IL-6 levels by ca. five fold. Despite this increase, only two samples presented IL-6 levels similar to those of the inflammation control. Considering these results, CMC showed potential to be a more natural alternative to traditional bioactive cosmetic ingredients and, as it is capable of being a bioactive and structural ingredient, it may play a key role in future skincare formulations.
Idioma original | English |
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Número do artigo | 6560 |
Páginas (de-até) | 1-16 |
Número de páginas | 16 |
Revista | Applied Sciences |
Volume | 12 |
Número de emissão | 13 |
DOIs | |
Estado da publicação | Publicado - 28 jun. 2022 |
Impressão digital
Mergulhe nos tópicos de investigação de “Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics“. Em conjunto formam uma impressão digital única.Projetos
- 1 Terminados
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ALCHEMY: Capturing High Value from Industrial Fermentation BioProducts
Pintado, M. M. (PI) & Pimentel, L. (Investigador)
1/01/18 → 30/06/23
Projeto