Chitosan and polyethylene glycol based membranes with antibacterial properties for tissue regeneration

Inês C. Pereira, Ana S. Duarte, Ana S. Neto, J. M. F. Ferreira*

*Autor correspondente para este trabalho

Resultado de pesquisarevisão de pares

20 Citações (Scopus)

Resumo

The prevention of microbial infections associated with implantable medical devices and superficial wounds represents one of the main research strategies in the field of biomaterials. The present study reports on the development of composite membranes of Chitosan (CS)-Polyethylene glycol (PEG) matrix, incorporating particles of biphasic calcium phosphate (BCP), zinc oxide (ZnO) and copper oxide (CuO). The properties that are relevant for intended applications in tissue regeneration and antibacterial coatings of implants were assessed. It was found that the addition of 1% (w/w - relative to the mass of CS) of each metal oxide promoted satisfactory bacteriostatic activity and exhibited no cytotoxic effects towards the Vero cell line. The formation of bonds between the CS/PEG matrix and ionic species from the powders enhanced the cross-linking degree and mechanical properties of composite membranes in comparison to the non-doped membrane with the same polymer matrix (CS/PEG = 70/30%). A gradual degradation of the composite membranes over the immersion time in simulated body fluid (SBF) was accompanied by a continuous surface deposition of uniform apatite layer.
Idioma originalEnglish
Páginas (de-até)606-615
Número de páginas10
RevistaMaterials Science and Engineering C
Volume96
DOIs
Estado da publicaçãoPublished - mar 2019
Publicado externamenteSim

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